From: Tertiary lymphoid structures associate with improved survival in early oral tongue cancer
Parameter | Number (%) | Disease-specific survival | Overall survival | ||
---|---|---|---|---|---|
Univariable analysis | Multivariable analysis | Univariable analysis | Multivariable analysis | ||
HR (95% CI) P value | HR (95% CI) P value | HR (95% CI) P value | HR (95% CI) P value | ||
Age | P = 0.02 | P < 0.02 | P < 0.001 | P < 0.001 | |
≤ 60 | 129 (41.6%) | Reference | Reference | Reference | Reference |
> 60 | 181 (58.4%) | 1.89 (1.11–3.21) | 1.94 (1.12–3.38) | 2.17 (1.55–3.03) | 2.32 (1.64–3.29) |
Gender | P = 0.46 | P = 0.59 | P = 0.13 | P = 0.015 | |
Men | 164 (52.9%) | Reference | Reference | Reference | Reference |
Women | 146 (47.1%) | 1.20 (0.73–1.97) | 1.15 (0.69–1.93) | 0.79 (0.57–1.08) | 0.66 (0.47–0.92) |
TNM AJCC 7 | P = 0.16 | P = 0.19 | P = 0.18 | P = 0.42 | |
T1N0M0 | 123 (39.7%) | Reference | Reference | Reference | Reference |
T2N0M0 | 187 (60.3%) | 1.47 (0.86–2.51) | 1.45 (0.83–2.52) | 1.26 (0.90–1.76) | 1.15 (0.82–1.63) |
TNM AJCC 8 | P = 0.30 | P = 0.29 | P = 0.43 | P = 0.98 | |
T1N0M0 | 89 (30.7%) | Reference | Reference | Reference | Reference |
T2N0M0 | 201 (69.3%) | 1.39 (0.75–2.59) | 1.41 (0.74–2.69) | 1.17 (0.79–1.70) | 1.00 (0.68–1.49) |
WHO Grade | P = 0.63 | P = 0.51 | P = 0.71 | P = 0.94 | |
Grade I & II | 235 (75.8%) | Reference | Reference | Reference | Reference |
Grade III | 75 (24.2%) | 1.15 (0.65–2.03) | 1.22 (0.68–2.20) | 0.93 (0.64–1.35) | 0.98 (0.67–1.45) |
Perineural invasion | P = 0.42 | P = 0.68 | P = 0.20 | P = 0.33 | |
No | 269 (86.8%) | Reference | Reference | Reference | Reference |
Yes | 41 (13.2%) | 1.32 (0.67–2.59) | 1.16 (0.58–2.29) | 1.32 (0.86–2.01) | 1.24 (0.81–1.90) |
Tertiary lymphoid structure | P = 0.012 | P = 0.025 | P = 0.007 | P = 0.014 | |
Present | 263 (84.8%) | Reference | Reference | Reference | Reference |
Absent | 47 (15.2%) | 2.11 (1.18–3.78) | 1.96 (1.09–3.54) | 1.73 (1.16–2.57) | 1.66 (1.11–2.48) |