Fig. 8
From: C9orf16 represents the aberrant genetic programs and drives the progression of PDAC
Blocking MYC signaling reduced cancer cell invasion and increased apoptosis. A MYRA-A and KSI-3716 treatment effectively blocked the activity of Myc signaling pathway in PANC-1 cells. B Real time PCR analysis of C9orf16 expression after MYRA-A and KSI-3716 treatment. C-D Western blotting analysis were performed to examine the expression of C9orf16 after the treatment of MYRA-A and KSI-3716 as well as recombinant human c-Myc protein. Migration and invasion assays (E) and cell number quantification (F) on cancer cells after MYRA-A and KSI-3716 treatment. Flow cytometry analysis (G) of Cisplatin induced cell apoptosis and percentage quantification of late apoptotic cells (H) of cancer cells after MYRA-A and KSI-3716 treatment. Scale bar: 100 µm. *: p < 0.05; **: p < 0.01; ***: p < 0.001; ****: p < 0.0001