Skip to main content

Table 1 SRB-based cytotoxicity of HepG2, Huh-7, and BHK-21 cell lines

From: Implication of extrinsic and intrinsic apoptotic pathways in the targeted therapy of hepatocellular carcinoma using aptamer-labeled viramidine nanoparticles

Cells/ IC50

VRM

APT

APT + VRM

VRM NPs

APT NPs

APT + VRM NPs

DOX

HepG2 cell line

43.07 ± 0.73

42.91 ± 3.20

38.61 ± 1.75

27.69 ± 1.35

31.09 ± 0.65

16.69 ± 1.12

88.56 ± 3.95

Huh-7 cell line

44.06 ± 2.50

50.21 ± 1.34

36.90 ± 2.35

20.13 ± 0.88

19.62 ± 0.57

11.23 ± 0.23

90.68 ± 0.71

BHK-21 cell line

90.43 ± 4.50

95.21 ± 3.25

94.15 ± 2.23

ND

ND

ND

86.25 ± 3.46

  1. IC50; the drug dosage at which 50% of the cells were killed. Units of the measured IC50; µM for VRM and DOX, while nM for APT. ND Not-detectable (means IC50 recorded more than 100 µM). HepG2 and Huh-7 cells; human hepatic cancerous cell lines. BHK-21 cell line; normal cell line