| PFS | OS | ||||||
---|---|---|---|---|---|---|---|---|
Univariable HR (95% CI) | P -value | Multivariable HR (95% CI) | P -value | Univariable HR (95% CI) | P -value | Multivariable HR (95% CI) | P -value | |
Hypothyroidism/Hyperthyroidism | 0.332 (0.131–0.842) | 0.020 | 0.291 (0.110–0.768) | 0.013 | 0.515 (0.199–1.334) | 0.172 | 0.518 (0.197–1.361) | 0.182 |
Diarrhea/Colitis | 0.743 (0.181–3.060) | 0.681 | 0.365 (0.083–1.610) | 0.183 | 0.350 (0.048–2.562) | 0.301 | 0.167 (0.020–1.403) | 0.099 |
Rash/Pruritus/Myalgia/Fatigue | 0.078 (0.011–0.579) | 0.013 | 0.065 (0.008–0.501) | 0.009 | 0.213 (0.029–1.558) | 0.128 | 0.216 (0.029–1.590) | 0.132 |
Hypohemoglobin/Thrombocytopenia | 1.469 (0.356–6.057) | 0.595 | 1.209 (0.290–5.038) | 0.794 | 2.240 (0.573–10.218) | 0.229 | 4.460 (0.935–21.279) | 0.061 |
Damage of liver or kidney function/Myocardial enzyme increased | 1.970 (0.710–5.464) | 0.193 | 2.778 (0.994–7.764) | 0.051 | 1.261 (0.376–4.232) | 0.707 | 1.066 (0.314–3.625) | 0.918 |