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Table 2 Comparison of clinical, histological, and PET/MRI parameters between the treatment failure and treatment response groups

From: Prognostic value of combined MTV and ADC derived from baseline FDG PET/MRI in aggressive non-Hodgkins lymphoma

Clinical and histological parameters

Treatment failure (n = 6)

Treatment response (n = 27)

P value

ECOG PS ≥2 n (%)

4 (67)

2 (7)

.05

HGBCL n (%)

2 (33)

1 (4)

.08

Age mean (range)

66.5 (50–75)

61.67 (33–82)

.41

Gender – male n (%)

4 (67)

18 (67)

.99

Number of extranodal sites ≥2 n (%)

3 (50)

9 (33)

.64

Ann Arbor stage III/IV n (%)

4 (67)

19 (70)

.99

Bulk n (%)

3 (50)

15 (56)

.99

IPI high ≥ 4–5 n (%)

2 (33)

6 (22)

.62

LDH elevated n (%)

4 (67)

16 (59)

.99

B-symptoms n (%)

3 (50)

9 (33)

.64

PET/MRI parameters

 ADCmean (mm2/s) mean (range)

941 (472–1721)

710 (292–1126)

.05

 ADCmin (mm2/s) mean (range)

466 (263–666)

357 (91–707)

.20

 MTV (cm3) mean (range)

784 (155–2752)

527 (4–2474)

.38

 MTV/ADCmean mean (range)

0.91 (0.15–2.92)

0.71 (0.01–3.62)

.61

 MTV/ADCmin mean (range)

1.68 (0.23–4.99)

1.64 (0.02–7.47)

.97

  1. ECOG PS Eastern Cooperative Oncology Group Performance Status, HGBCL High-grade B-cell lymphoma, IPI International Prognostic Index, LDH Lactate Dehydrogenase, ADC Apparent diffusion coefficient, MTV Metabolic tumor volume