A predictive model based on site-specific risk factors of recurrence regions in endometrial cancer patients

Shin, Wonkyo; Yang, Seong J.; Park, Sang-Yoon; Kang, Sokbom; Lee, Dong Ock; Lim, Myong Cheol; Seo, Sang-Soo

doi:10.1186/s12885-022-10193-3

Table 3 Multinomial logistic regression analysis of clinical factors that related to site specific recurrence

From: A predictive model based on site-specific risk factors of recurrence regions in endometrial cancer patients

Variables	value	No.	binomial logistic model				multinomial logistic model
			Total recurrene (N = 57)				Local recurrence (N = 20)				Regional recurrence (N = 12)				Distant recurrence (N = 25)
			risk ratio	95% CI		p	risk ratio	95% CI		p	risk ratio	95% CI		p	risk ratio	95% CI		p
Surgical approach	Laparoscopy	392	reference level
Surgical approach	Laparotomy	162	0.788	0.339	1.808	0.575	0.681	0.198	2.342	0.542	1.164	0.182	7.455	0.873	0.902	0.267	3.045	0.868
Pelvic LN	negative	418	reference level
	positive	37	0.362	0.083	1.433	0.157	0.039	0.001	1.926	0.103	2.380	0.112	50.632	0.578	0.425	0.076	2.363	0.328
	not done	99	2.003	0.559	7.733	0.295	3.642	0.557	23.820	0.177	0.424	0.046	3.871	0.447	> 100	> 100	> 100	< 0.001
paraaortic LN	Negative	309	reference level
	Positive	27	1.912	0.500	7.923	0.352	3.051	0.267	34.840	0.369	1.740	0.114	26.460	0.690	2.473	0.479	12.760	0.279
	not done	218	1.023	0.313	3.007	0.968	0.741	0.133	4.126	0.732	14.820	1.407	156.100	0.025	0.000	0.000	0.000	< 0.001
LVSI	No	454	reference level
LVSI	Yes	100	1.954	0.788	4.847	0.146	2.357	0.676	8.210	0.178	3.494	0.481	25.393	0.216	1.594	0.417	6.098	0.496
Histology	Endometrioid	467	reference level
Histology	Non-endometrioid	87	0.602	0.160	1.962	0.422	1.514	0.333	6.890	0.591	0.000	0.000	0.000	< 0.001	0.292	0.035	2.453	0.257
FIGO grade	1	280	reference level
	2	150	1.335	0.479	3.837	0.583	0.945	0.252	3.546	0.934	1.384	0.093	20.683	0.814	2.187	0.358	13.377	0.397
	3	70	0.264	0.049	1.142	0.091	0.000	0.000	0.000	< 0.001	2.044	0.108	38.800	0.634	0.450	0.047	4.346	0.490
	N/A	54	1.418	0.308	7.162	0.661	0.323	0.043	2.396	0.269	> 100	> 100	> 100	< 0.001	4.970	0.334	74.020	0.245
Parametrial invasion	No	552	reference level
Parametrial invasion	Yes	2	34.183	6.010	305.46	< 0.001	109.94	1.595	7576.60	0.030	68.300	3.865	1206.90	0.004	36.040	3.984	325.900	0.001
FIGO stage	I II	492	reference level
FIGO stage	III IV	62	0.548	0.164	1.651	0.303	0.280	0.041	1.896	0.192	0.669	0.078	5.732	0.714	0.536	0.102	2.834	0.463
Chemotherapy	No	397	reference level
Chemotherapy	Yes	157	67.174	17.750	447.497	< 0.001	36.500	6.716	198.400	< 0.001	> 100	> 100	> 100	< 0.001	> 100	> 100	> 100	< 0.001
Age (Continuous)	age	-	1.037	0.998	1.079	0.068	1.032	0.976	1.091	0.269	1.110	1.022	1.206	0.013	1.002	0.945	1.061	0.959
tumor size (continuous)	size	-	1.041	0.896	1.208	0.593	1.083	0.852	1.378	0.514	1.143	0.857	1.525	0.362	1.023	0.846	1.236	0.817
Myometrial invasion		-	4.911	1.205	20.655	0.027	10.605	1.565	71.868	0.016	0.115	0.003	3.963	0.231	7.446	0.890	62.262	0.064

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