Fig. 9
From: Obese mammary tumour-bearing mice are highly sensitive to doxorubicin-induced hepatotoxicity
Summary of schematic representation of DXR-induced hepatotoxicity in an obese-tumour bearing mouse model. Demonstrating the effects of diet-induced obesity, breast tumours and DXR treatment on the outcomes of hepatotoxicity. Diet-induced obesity resulted in an increase in adiposity, body weight, and hepatic tissue weight in mice fed a HFD. Diet-induced obesity in the presence of breast tumours treated with DXR caused significant structural modifications to hepatic tissue and exacerbated the hepatoxicity in the obese tumour bearing mice. There was no evidence of fibrosis which indicates that the livers did not progress to cirrhosis