Fig. 3

Invasive ability of and CCR7 and let-7a expression in KYSE-510 cells after six invasion assays. A Increased invasive ability after invasion assay (KYSE-510: p < 0.001, KYSE-590: p = 0.001). B Increased number of KYSE-510 and -590 cells migrated after invasion assay (cells are shown in the area surrounded by square). C Increased expression level of CCR7 in synthesized highly invasive cell lines (KYSE-510: p = 0.004, KYSE-590: p = 0.203). D Decreased expression level of let-7a in synthesized highly invasive cell lines (KYSE-510: p < 0.001, KYSE-590: p = 0.001). (* p < 0.05 versus wild-type)