Personalized targeted therapy prescription in colorectal cancer using algorithmic analysis of RNA sequencing data

BMC Cancer

Table 3 Characteristic of targeted drugs investigated in the experimental group

Drug generic name	Molecular target(s)	Reference for molecular target	Drug use in CRC	Reference for drug use
Bevacizumab	VEGF	[56]	Approved for advanced CRC	[7]
Aflibercept	VEGFA, VEGFB, PGF	[57]	Approved for CRC	[58]
Bortezomib	PSMB5, PSMB1	[59]	Off-label for CRC	[60]
Cabozantinib	MET, KDR	[61]	Off-label for CRC	[62]
Cetuximab	EGFR	[63] [64]	Approved for metastatic CRC	[65]
Crizotinib	ALK, MET	[66]	Off-label for CRC	[67]
Panitumumab	EGFR	[68]	Approved for metastatic CRC	[69]
Regorafenib	RET, VEGFR1, VEGFR2, VEGFR3, KIT, PDGFR-alpha, PDGFR-beta, FGFR1, FGFR2, TIE2, DDR2, TrkA, Eph2A, RAF-1, BRAF, SAPK2, PTK5, and Abl	[70]	Approved for metastatic CRC	[9]
Denosumab	TNFSF11	[71]	Off-label for CRC	[72]

ISSN: 1471-2407