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Table 3 Association of gender with clinicopathological characteristics of MTC

From: Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects

Characteristics

N (%)

P value

 

Total

Male

Female

 

Age at surgery(year)

   

0.391

≤ 52

101(54.0)

43(42.6)

58(57.4)

 

>52

86(46.0)

42(48.8)

44(51.2)

 

Heredity

   

0.122

Hereditary

33(17.6)

18(54.5)

15(45.5)

 

sporadic

154(82.4)

92(59.7)

62(40.3)

 

Multifocal

   

0.334

Yes

55(29.4)

28(50.9)

27(49.1)

 

No

132(70.6)

57(43.2)

75(56.8)

 

ETE

   

0.302

Yes

76(40.6)

38(50.0)

38(50.0)

 

No

111(59.4)

47(42.3)

64(57.7)

 

Bilateral lesions

   

0.666

Yes

20(10.7)

10(50.0%)

10(50.0%)

 

No

167(89.3)

75(44.9)

92(55.1)

 

Tumor size(cm)

   

0.572

≤ 2

120(64.2)

55(45.8)

65(54.2)

 

2–4

57(30.5)

24(42.1)

33(57.9)

 

>4

10(5.3)

6(60.0)

4(40.0)

 

pT stage

   

0.358

T1/T2

108(57.7)

46(42.6)

62(57.4)

 

T3/T4

79(42.3)

39(49.4)

40(50.6)

 

pN stage

   

<0.001 *

N0

87(46.5)

28(32.2)

59(67.8)

 

N1a

26(13.9)

12(46.2)

14(53.8)

 

N1b

74(39.6)

45(60.8)

29(39.2)

 

8th TNM stage

   

<0.001 *

I/II

77(41.1)

21(27.3)

56(72.7)

 

III/IV

110(58.9)

64(58.2)

46(41.8)

 

Coexist HT

   

0.086

Yes

24(12.8)

7(29.2)

17(70.8)

 

No

163(87.2)

78(47.9)

85(52.1)

 

Pathology

   

0.290

Only MTC

105(56.1)

53(50.5)

52(49.5)

 

With adenomatous goiter

9(4.8)

5(55.6)

4(44.4)

 

With nodular goiter

51(27.3)

18(35.3)

33(64.7)

 

With PTC

22(11.8)

9(40.9)

13(59.1)

 

Recurrence

   

0.649

Yes

22(11.8)

11(50.0)

11(50.0)

 

No

165(88.2)

74(44.8)

91(55.2)

 

Biochemical cure

   

0.649

Yes

98(52.4)

43(43.9)

55(56.1)

 

No

89(47.6)

42(47.2)

47(52.8)

 

IDO2 expression

   

0.017 *

High

77(41.1)

43(55.8)

34(44.2)

 

Low

110(58.9)

42(38.2)

68(61.8)

 
  1. *P<0.05; MTC, medullary thyroid carcinoma; IDO2, indoleamine 2,3-dioxygenase 2; ETE, extrathyroid extension; HT, Hashimoto’s thyroiditis