Chemotherapy dose per kilogram lean body mass increased dose-limiting toxicity event in male head and neck cancer with taxane and platinum-based induction therapy

Table 3 Distribution of body composition factors and dose-limiting toxicity events in male and female head and neck cancer patients

Variables	Males (n = 163)	Females (n = 16)	P value
Body composition factors and chemotherapy dose per kilogram LBM
BMI	23.6 ± 4.1	22.5 ± 3.1	0.901
LBM	41.4 ± 5.5	28.5 ± 4.5	< 0.001
SMI	48.9 ± 6.6	37.4 ± 5.4	< 0.001
Docetaxel/LBM	2.5 ± 0.31	3.3 ± 0.33	< 0.001
Cisplatin/LBM	2.45 ± 0.31	3.3 ± 0.33	< 0.001
Outcome
DLT events	41(25.2%)	2(12.5%)	0.258

Abbreviation: BMI Body mass index, LBM Lean body mass, SMI Skeletal muscle index, DLT events Dose-limiting toxicity events

ISSN: 1471-2407