Dose (mg/kg) | n | Cmax (μg/mL) | AUC0-∞ (h*μg/mL) | CL_obs (mL/h/kg) | T1/2 (h) | Tmax (h)a | Vz_obs (ml/kg) |
---|---|---|---|---|---|---|---|
0.5 | 3 | 7.7 (13.2) | 216.7 (17.7) | 2.3 (17.7) | 17.6 (7.6) | 2.5 (2.5–2.5) | 58.7 (10.8) |
1.0 | 3 | 15.8 (11.4) | 665.7 (12.7) | 1.5 (12.7) | 20.0 (4.8) | 2.7 (2.5–4.0) | 43.3 (16.1) |
2.0 | 3 | 36.7 (20.4) | 2,048.8 (44.2) | 1.0 (44.2) | 36.7 (57.7) | 2.5 (2.5–7.6) | 51.7 (22.1) |
4.0 | 4 | 74.6 (11.9) | 8,037.3 (15.9) | 0.5 (15.9) | 52.9 (40.0) | 5.2 (2.5–8.0) | 37.9 (31.8) |
6.0 | 6 | 109.0 (10.0) | 13,176.4 (19.9) | 0.5 (19.9) | 67.2 (37.8) | 2.5 (2.5–4.0) | 44.1 (42.1) |
8.0 | 3 | 186.7 (26.9) | 27,216.0 (31.2) | 0.3 (31.2) | 75.9 (115.8) | 2.5 (2.5–2.5) | 32.2 (75.4) |