Skip to main content

Table 2 Clinicopathological factors according to the number of MUC16 mutations

From: Overview and clinical significance of multiple mutations in individual genes in hepatocellular carcinoma

Variable

Wild-type

Single mutation

Multiple mutations

P-value

N = 177

N = 39

N = 7

Gender, N, (%)

 Male

145 (82%)

31 (79%)

6 (86%)

 < 0.001

 Female

32 (18%)

8 (21%)

1 (14%)

Age, years, (IQR)

70 (64–76)

74 (68–78)

65 (64–73)

0.022

HBV or HCV, N, (%)

 HCV

53 (30%)

11 (28%)

5 (71%)

 < 0.001

 HBV

34 (19%)

8 (21%)

0 (0%)

 NBNC

90 (51%)

20 (51%)

2 (29%)

ICG-R15, %, (IQR)

9.5 (6.1–13.7)

10.7 (7.5–15.7)

13.4 (5.9–15.1)

0.445

AFP, ng/ml, (IQR)

9.2 (3.7–144.1)

5.2 (2.3–24.2)

641.4 (7.4–883.7)

0.107

PIVKAII, mAU/ml, (IQR)

116.0 (32.6–1495.0)

414.0 (24.8–3537.5)

5670.0 (160.0–37,800.0)

0.032

Tumor size, mm, (IQR)

35 (22–65)

36 (25–76)

63 (33–78)

 

Macrovascular invasion, N, (%)

 Positive

12 (7%)

1 (3%)

2 (29%)

0.041

Microvascular invasion, N, (%)

 Positive

58 (33%)

15 (38%)

2 (29%)

0.761

  1. Continuous variables expressed as median and interquartile range (IQR)
  2. Significant values are in bold
  3. HBV Hepatitis B virus, HCV Hepatitis C virus, ICG Indocyanine green, AFP Alpha fetoprotein, NBNC Non B non C