Table 1 Univariate and multivariate analyses for relapse-free survival after hepatectomy

Genetic signatures

 Tumor mutation burden

  Hyper

146

1.41

0.97–2.10

0.079

  Hypo

77

 Multiple mutations

  Present

178

1.97

1.19–3.53

0.012

1.72

1.01–3.17

0.045

  Absent

45

Clinicopathological factors

 Sex

  Male

182

1.22

0.78–2.01

0.402

  Female

41

 Age, years

   ≥ 70

114

0.97

0.69–1.39

0.893

   < 70

109

 HBV or HCV

  Negative

112

0.92

0.65–1.31

0.655

  Positive

111

 ICG-R15, %

   ≥ 20

13

1.30

0.64–2.36

0.424

   < 20

210

 AFP, ng/ml

   ≥ 200

48

1.40

0.91–2.09

0.106

   < 200

171

 PIVKA-II, mAU/ml

   ≥ 100

121

1.84

1.27–2.69

0.001

1.34

0.88–2.06

0.177

   < 100

95

 Tumor size, mm

   ≥ 30

132

1.68

1.16–2.46

0.006

1.23

0.84–1.96

0.257

   < 30

91

 Macrovascular invasion

  Positive

15

2.43

1.23–4.32

0.004

1.72

0.86–3.10

0.119

  Negative

208

 Microvascular invasion

  Positive

75

2.26

1.58–3.22

 < 0.001

1.96

1.36–2.83

 < 0.001

  Negative

148

 Liver damage

  Liver cirrhosis

88

1.36

0.95–1.94

0.085

  No cirrhosis

135