Fig. 2

Frequent MMs in a variety of oncogenes in HCC. a The percentages of samples with wild type, single mutation, and multiple mutations for 14 genes with 20 or more mutated samples in the present cohort (n = 223). Correlations between MMs in CTNNB1 (b) and MUC16 (c) and TMB were found between samples with SM and samples with the wild-type gene (CTNNB1, P < 0.001; MUC16, P = 0.001, Mann–Whitney U test) but not between SM and MMs (CTNNB1, P = 0.710, MUC16, P = 0.531, Mann–Whitney U test). The signature 16 was significantly higher in samples with MMs in CTNNB1 than samples with the wild-type CTNNB1, although no significant differences in the signature score between samples with SM in CTNNB1 and samples with the wild-type CTNNB1 (d). No significant differences in the signature 16 score according tot the mutational status in MUC16 (e). The impact of MMs on gene expression in CTNNB1 (f) and MUC16 (g)