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Table 3 Number and PAFs of colorectal neoplasms attributable to selected risk factors

From: Modifiable lifestyle factors have a larger contribution to colorectal neoplasms than family history

 

Male

Female

Adjusted PAFa (95% CI)

Cases attributable to risk factorb

Adjusted PAFa (95% CI)

Cases attributable to risk factorb

For nonadvanced CRN

 Current smoking

8.9% (6.6% to 11.1%)

871/9788

3.4% (1.6% to 5.2%)

273/8035

 Ever drinking

2.6% (0.6% to 4.6%)

254/9788

0.4% (-1.4% to 2.2%)

32/8035

 Physical inactivity

1.9% (-1.6% to 5.3%)

186/9788

2.1% (-1.5% to 5.7%)

169/8035

 BMI > 25 kg/m2

5.8% (3.1% to 8.5%)

567/9788

7.8% (5.1% to 10.4%)

627/8035

 History of CRC in FDR

1.1% (-0.5% to 2.7%)

108/9788

0.7% (-1.2% to 2.7%)

56/8035

 All selected lifestyle risk factorsc

19.9% (14.4% to 25.3%)

1948/9788

9.7% (5.1% to 14.2%)

779/8035

For advanced CRN

 Current smoking

12.3% (7.9% to 16.8%)

261/2126

4.3% (-0.8% to 9.5%)

54/1255

 Ever drinking

7.3% (3.0% to 11.5%)

155/2126

0.2% (-5.1% to 5.5%)

3/1255

 Physical inactivity

4.9% (-1.1% to 10.9%)

104/2126

8.2% (0.6% to 15.8%)

103/1255

 BMI > 25 kg/m2

7.2% (1.8% to 12.6%)

153/2126

8.5% (1.9% to 15.1%)

107/1255

 History of CRC in FDR

0.8% (-3.2% to 4.8%)

17/2126

-0.6% (-6.2% to 5%)

8/1255

 All selected lifestyle risk factorsc

29.0% (20.4% to 37.6%)

617/2126

13.8% (4.2% to 23.3%)

173/1255

  1. PAF Population attributable fraction, CI Confidence interval, CRN Colorectal neoplasm, BMI Body mass index, CRC Colorectal cancer, FDR First-degree relative
  2. a PAFs were adjusted for age at colonoscopy, educational level, marital status, smoking status, alcohol intake, physical activity, BMI, family history of CRC in first-degree relative and year of colonoscopy
  3. b [Total number of cases × PAF] / total number of cases
  4. c Selected lifestyle risk factors including current smoking, alcohol drinking, physical inactivity and BMI > 25 kg/m2