Table 2 Association of selected risk factors with colorectal neoplasms stratified by sex

For nonadvanced CRN

 Smoking status (vs. never)

  Former

743 (7.6)

0.93 (0.83–1.04)

0.233

110 (1.4)

1.12 (0.87–1.44)

0.379

  Current

3484 (35.6)

1.31 (1.22–1.40)

 < 0.001

630 (7.8)

1.79 (1.59–2.02)

 < 0.001

 Alcohol consumption (vs. never)

  Ever drinker

2190 (22.4)

1.14 (1.06–1.23)

 < 0.001

88 (1.1)

1.54 (1.13–2.10)

0.007

 Physical activity (vs. regular activity)

  Physical inactivity

5241 (53.5)

1.01 (0.95–1.08)

0.665

4512 (56.2)

1.02 (0.96–1.08)

0.542

 BMI, kg/m² (vs. < 25)

  25–29.9

3916 (40.0)

1.12 (1.05–1.19)

 < 0.001

2916 (36.3)

1.19 (1.12–1.26)

 < 0.001

   ≥ 30

624 (6.4)

1.36 (1.19–1.54)

 < 0.001

630 (7.8)

1.36 (1.22–1.52)

 < 0.001

 Family history of CRC in FDR (vs. no)

  Yes

757 (7.7)

1.13 (1.01–1.27)

0.026

707 (8.8)

1.08 (0.98–1.19)

0.134

For advanced CRN

 Smoking status (vs. never)

  Former

156 (7.3)

0.84 (0.70–1.02)

0.083

22 (1.8)

1.38 (0.87–2.19)

0.174

  Current

821 (38.6)

1.42 (1.27–1.58)

 < 0.001

112 (8.9)

2.05 (1.64–2.57)

 < 0.001

 Alcohol consumption (vs. never)

  Ever drinker

574 (27.0)

1.41 (1.25–1.59)

 < 0.001

12 (1.0)

1.20 (0.64–2.25)

0.565

 Physical activity (vs. regular activity)

  Physical inactivity

1089 (51.2)

1.05 (0.95–1.16)

0.346

697 (55.5)

1.11 (0.98–1.26)

0.094

 BMI, kg/m² (vs. < 25)

  25–29.9

869 (40.9)

1.15 (1.04–1.28)

0.006

457 (36.4)

1.20 (1.06–1.36)

0.005

   ≥ 30

148 (7.0)

1.49 (1.21–1.82)

 < 0.001

112 (8.9)

1.54 (1.24–1.92)

 < 0.001

 Family history of CRC in FDR (vs. no)

  Yes

151 (7.1)

1.13 (0.93–1.36)

0.221

92 (7.3)

0.92 (0.74–1.16)

0.484