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Table 5 Areas under the curve (AUC), sensitivity, and specificity measurements for G-test and AAR (single and combination) between AFP-NHCC versus HCC

From: The combination of serum oligosaccharide chain (G-test), alpha-fetoprotein, and aspartate aminotransferase to alanine aminotransferase ratio provides the optimal diagnostic value for early detection of hepatocellular carcinoma

Variables

AUC

Cut-offs

Sensitivity (%)

Specificity (%)

Youden index

+LR

-LR

+PV

-PV

p value

G-Test

0.855 (0.762–0.922)

4.73

83.8 (68.0-93.8)

87.5 (74.8–95.3)

0.713

6.7 (3.1–14.4)

0.19 (0.09–0.4)

93.8 (70.7–91.7)

87.5 (77.0-93.6)

< 0.001

AAR

0.500 (0.389–0.611)

1.34

54.0 (36.9–70.5)

53.2 (38.1–67.9)

0.072

1.2 (0.8–1.8)

0.86 (0.6–1.3)

47.6 (37.3–58.2)

59.5 (48.6–69.6)

0.996

G-Test + AAR

0.852 (0.758–0.920)

0.44

83.8 (68.0-93.8)

87.2 (74.3–95.2)

0.710

6.6 (3.1–14.0)

0.19 (0.09–0.4)

83.8 (70.7–91.7)

87.2 (76.5–93.5)

< 0.001

  1. ±LR: positive/negative likelihood ratio; ±PV: positive/negative predictive value; AAR: aspartate aminotransferase to alanine aminotransferase ratio; AFP: alpha-fetoprotein; AFP-NHCC: alpha-fetoprotein negative hepatocellular carcinoma; AUC: area under the curve; G-test: serum oligosaccharide chain; HCC: hepatocellular carcinoma