| AUC | Cut-offs | Sensitivity (%) | Specificity (%) | Youden index | +LR | -LR | +PV | -PV | p value |
---|---|---|---|---|---|---|---|---|---|---|
Healthy vs. HCC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
G-Test | 0.953 (0.890–0.986) | 4.73 | 90.9 (82.2–96.3) | 100.0 (83.2–100.0) | 0.909 |  | 0.091 (0.04–0.2) | 100.0 | 74.1 (58.5–85.3) | < 0.001 |
AFP | 0.827 (0.736–0.896) | 5.28 | 61.0 (49.2–72.0) | 95.0 (75.1–99.9) | 0.560 | 12.2 (1.8–83.2) | 0.4 (0.3–0.6) | 97.9 (87.3–99.7) | 38.8 (32.0–46.0) | < 0.001 |
AAR | 0.546 (0.441–0.648) | 1.75 | 70.1 (58.6–80.0) | 47.4 (24.4–71.1) | 0.175 | 1.3 (0.8–2.1) | 0.63 (0.4–1.1) | 84.4 (77.5–89.4) | 28.1 (17.9–41.2) | 0.552 |
G-Test + AFP + AAR | 0.958 (0.896–0.988) | 0.839 | 88.3 (79.0-94.5) | 100.0 (82.4–100.0) | 0.883 |  | 0.12 (0.06–0.2) | 100.0 | 67.9 (53.3–79.6) | < 0.001 |
Hepatitis vs. HCC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
G-Test | 0.786 (0.690–0.864) | 4.47 | 90.9 (82.2–96.3) | 77.8 (52.4–93.6) | 0.687 | 4.1 (1.7–9.7) | 0.1 (0.06–0.2) | 94.6 (88.0-97.7) | 66.7 (48.6–80.9) | < 0.001 |
AFP | 0.652 (0.547–0.746) | 96.14 | 58.4 (46.6–69.6) | 77.8 (52.4–93.6) | 0.362 | 2.6 (1.1–6.4) | 0.5 (0.4–0.8) | 91.8 (82.3–96.5) | 30.4 (23.3–38.6) | 0.013 |
AAR | 0.850 (0.762–0.915) | 1.53 | 96.1 (89.0-99.2) | 72.2 (46.5–90.3) | 0.683 | 3.5 (1.6–7.3) | 0.1 (0.02–0.2) | 93.7 (87.5–96.9) | 81.2 (57.9–93.2) | < 0.001 |
G-Test + AFP + AAR | 0.898 (0.818–0.950) | 0.83 | 81.8 (71.4–89.7) | 88.9 (65.3–98.6) | 0.707 | 7.4 (2.0-27.3) | 0.2 (0.1–0.3) | 96.9 (89.5–99.2) | 53.3 (40.9–65.4) | < 0.001 |
Cirrhosis vs. HCC | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
G-Test | 0.792 (0.705–0.862) | 5.58 | 84.4 (74.4–91.7) | 73.0 (55.9–86.2) | 0.574 | 3.1 (1.8–5.3) | 0.2 (0.1–0.4) | 86.7 (79.1–91.8) | 69.2 (56.3–79.7) | < 0.001 |
AFP | 0.655 (0.561–0.742) | 201.8 | 36.4 (25.7–48.1) | 94.6 (81.8–99.3) | 0.31 | 6.7 (1.7–26.7) | 0.8 (0.6–0.8) | 93.3 (77.9–98.2) | 41.7 (37.2–46.2) | 0.003 |
AAR | 0.544 (0.448–0.638) | 0.58 | 33.8 (23.4–45.4) | 81.1 (64.8–92.0) | 0.149 | 1.8 (0.9–3.7) | 0.8 (0.7-1.0) | 78.8 (64.0-88.6) | 37.0 (32.0-42.4) | 0.427 |
G-Test + AFP + AAR | 0.808 (0.723–0.876) | 0.62 | 89.6 (80.6–95.4) | 67.6 (50.2–82.0) | 0.572 | 2.8 (1.7–4.4) | 0.2 (0.08–0.3) | 85.2 (78.2–90.2) | 75.8 (61.0-86.2) | < 0.001 |