Table 3 Factors related to detection of †EGFR mutation by liquid biopsy
|  | EGFR mutation positive (n = 19) | EGFR mutation negative (n = 11) | P value |
|---|---|---|---|
Age, median (range), years | 68.0 (54–82) | 69.0 (55–81) | 0.5315 |
histology, n (%) (adenocarcinoma/ adenosquamous) | 19 (89.4%) (17/2) | 11 (100%) (11/0) | 0.5195 |
N2 or higher, n (%) | 13 (68.4%) | 5 (45.4%) | 0.2663 |
M factor, n (%) | 18 (89.4%) | 9 (81.8%) | 0.5367 |
LDH, median, U/L | 217 | 189 | 0.0776 |
ALP, median, U/L | 304 | 225 | 0.0048 |
CRP, median, mg/dl | 0.53 | 0.12 | 0.0501 |
CEA, median, ng/mL | 39.1 | 10.6 | 0.2307 |
extrathoracic metastasis, n (%) | 17 (89.4%) | 3 (27.2%) | 0.0010 |
brain metastasis, n (%) | 7 (36.8%) | 0 | 0.0292 |
liver metastasis, n (%) | 5 (26.3%) | 0 | 0.0527 |
adrenal metastasis, n (%) | 7 (36.8%) | 0 | 0.0292 |
bone metastasis, n (%) | 12 (63.1%) | 3 (27.2%) | 0.1281 |