Table 2 Histopathological aspects evaluated according to each subgroup
Parameters | Total n = 200 | HPV n = 113 | IHC n = 173 |
|---|---|---|---|
Surgical procedure | N (%) | N (%) | N (%) |
  Preservative (exeresis) | 7 (3.5) | 0 (0.0) | 5 (2.9) |
  Total glansectomy | 7 (3.5) | 4 (3.5) | 7 (4.0) |
  Partial penectomy | 145 (72.5) | 80 (70.8) | 126 (72.8) |
  Total penectomy | 28 (14.0) | 19 (16.8) | 24 (13.9) |
  Emasculation | 13 (6.5) | 10 (8.8) | 11 (6.4) |
Topography | |||
  Foreskin and/or coronal sulcus | 8 (4.0) | 2 (1.8) | 7 (4.1) |
  Glans | 88 (44.4) | 41 (36.3) | 75 (43.6) |
  Corpus | 7 (3.5) | 3 (2.7) | 5 (2.9) |
  Glans + foreskin and/or coronal sulcus | 54 (27.3) | 38 (33.6) | 47 (27.3) |
  Glans + corpus | 40 (20.2) | 29 (25.6) | 37 (21.5) |
  Others | 1 (0.5) | 0 (0.0) | 1 (0.6) |
  No information | 2 | 0 | 1 |
Size (cm) | |||
  0.6 – 2.0 | 18 (9.3) | 9 (8.0) | 17 (10.1) |
  2.1 – 5.0 | 120 (61.9) | 64 (57.1) | 100 (59.2) |
  5.1 – 10.0 | 54 (27.8) | 37 (33.0) | 50 (29.6) |
   > 10.0 | 2 (1.0) | 2 (1.8) | 2 (1.2) |
  No information | 6 | 1 | 4 |
Macroscopic aspects | |||
  Ulcerative | 61 (30.8) | 34 (30.1) | 50 (29.1) |
  Vegetative | 46 (23.2) | 34 (30.1) | 44 (25.6) |
  Verrucous | 11 (5.6) | 7 (6.2) | 9 (5.2) |
  Ulcerative-vegetative | 51 (25.8) | 28 (24.8) | 44 (25.6) |
  Others | 29 (14.6) | 10 (8.8) | 25 (14.5) |
  No information | 2 | 0 | 1 |
Histological type | |||
  Squamous cell carcinoma | 200 (100.0) | 113 (100.0) | 173 (100.0) |
Histological subtype | |||
  Usual | 79 (39.5) | 44 (38.9) | 65 (37.6) |
  Warty | 58 (29.0) | 32 (28.3) | 52 (30.1) |
  Basaloid | 8 (4.0) | 6 (5.3) | 8 (4.6) |
  Warty-basaloid | 17 (8.5) | 8 (7.1) | 14 (8.1) |
  Mixeda | 32 (16.0) | 21 (18.6) | 30 (17.3) |
  Othersb | 6 (3.0) | 2 (1.8) | 4 (2.3) |
Grade (G) | |||
  G1 | 25 (12.5) | 14 (12.4) | 20 (11.6) |
  G2 | 77 (38.5) | 36 (31.9) | 65 (37.6) |
  G3 | 98 (49.0) | 63 (55.8) | 88 (50.9) |
Angiolymphatic invasion | |||
  Detected | 71 (35.5) | 47 (41.6) | 64 (37.0) |
  Not detected | 129 (64.5) | 66 (58.4) | 109 (63.0) |
Perineural invasion | |||
  Detected | 73 (36.5) | 45 (39.8) | 64 (37.0) |
  Not detected | 127 (63.5) | 68 (60.2) | 109 (63.0) |
Tumor focus | |||
  Unifocal | 178 (89.9) | 97 (85.8) | 152 (88.4) |
  Multifocal | 20 (10.1) | 16 (14.2) | 20 (11.6) |
  No information | 2 | 0 | 1 |
Carcinoma in situ—associated | |||
  Present | 164 (82.0) | 92 (81.4) | 143 (82.7) |
  Absent | 36 (18.0) | 21 (18.6) | 30 (17.3) |
Sarcomatoid component | |||
  Present | 34 (17.1) | 24 (21.2) | 31 (17.9) |
  Absent | 165 (82.9) | 89 (78.8) | 142 (82.1) |
  No information | 1 | 0 | 0 |
Lichen sclerosus | |||
  Present | 53 (27.3) | 27 (24.5) | 44 (26.0) |
  Absent | 141 (72.7) | 83 (75.5) | 125 (74.0) |
  No information | 6 | 3 | 4 |
Koilocytosis | |||
  Present | 157 (78.5) | 97 (85.8) | 140 (80.9) |
  Absent | 43 (21.5) | 16 (14.2) | 33 (19.1) |
Primary tumor (T) | |||
  pT1a | 42 (21.0) | 16 (14.2) | 35 (20.2) |
  pT1b | 3 (1.5) | 1 (0.9) | 3 (1.7) |
  pT2 | 53 (26.5) | 31 (27.4) | 46 (26.6) |
  pT3 | 96 (48.0) | 61 (54.0) | 84 (48.6) |
  pT4 | 6 (3.0) | 4 (3.5) | 5 (2.9) |
Stage | |||
  I | 42 (21.0) | 16 (14.2) | 35 (20.2) |
  IIa | 53 (26.5) | 30 (26.5) | 46 (26.6) |
  IIb | 88 (44.0) | 55 (48.7) | 77 (44.5) |
  IIIa | 1 (0.5) | 0 (0.0) | 1 (0.6) |
  IIIb | 1 (0.5) | 1 (0.9) | 1 (0.6) |
  IV | 15 (7.5) | 11 (9.7) | 13 (7.5) |
Pattern of invasion | |||
  Expansive | 140 (75.3) | 79 (73.8) | 124 (75.6) |
  Infiltrative | 44 (23.7) | 26 (24.3) | 38 (23.2) |
  Others | 2 (1.1) | 2 (1.9) | 2 (1.2) |
  No information | 14 | 6 | 9 |
Tumor thickness (mm) | |||
  ≤ 5.0 | 73 (39.0) | 39 (35.8) | 68 (41.2) |
  > 5.0 | 114 (61.0) | 70 (64.2) | 97 (58.8) |
  No information | 13 | 4 | 8 |
Depth of invasion (mm) | |||
  ≤ 5.0 | 97 (52.4) | 53 (49.1) | 89 (54.3) |
  > 5.0—≤ 10.0 | 61 (33.0) | 35 (32.4) | 51 (31.1) |
  > 10.0 | 27 (14.6) | 20 (18.5) | 24 (14.6) |
  No information | 15 | 5 | 9 |