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Table 1 Characteristics of R1 patients first operated outside NETSARC reference centers (n=1,029). Data are mean (SD) or n (%). MDTB: MultiDisciplinary Tumor Board. Percentages might not add up to 100% due to rounding. KW: Kruskal-Wallis

From: Overall survival in patients with re-excision of positive microscopic margins of limb and trunk wall soft tissue sarcoma operated outside of a reference center: a nationwide cohort analysis

 

R1 patients non re–excised (noRE),

n =331

R1 patients re–excised (RE),

n =698

R1 patients re–excised (RE) or not (NoRE)

n= 1,029

p value for R1 patients noRE versus RE

Gender

 Female

147 (44%)

313 (45%)

460 (44.7%)

Chi-2 p =0.897

 Male

184 (56%)

385 (55%)

569 (55.3%)

 

Age at diagnostic

59.5 (21.2)

57.1 (18.3)

57.88 (19.31)

Chi 2 p =0.011

Site of the tumor

   

KW p =0.020

 Trunk wall

134 (41%)

206 (30%)

445 (43.2%)

 

 Upper limb

62 (19%)

182 (26%)

340 (33.0%)

 

 Lower limb

135 (41%)

310 (44%)

244 (23.7%)

 

Size of the tumor (mm)

72.8 (58.5)

47.9 (40.5)

55.75 (48.3)

KW p <0.001

Depth of the tumor

  

45 (5-500)

Chi-2 p <0.001

 Superficial (Sus–facia)

89 (29%)

303 (46%)

392 (40.9%)

 

 Deep (Sub-facia)

214 (71%)

352 (54%)

566 (59.1%)

 

Histology

 Liposarcoma

62 (19%)

85 (12%)

147 (14.3%)

Chi-2 p =0.001

 Synovial sarcoma

21 (6%)

32 (5%)

53 (5.2%)

 

 Leiomyosarcoma

48 (14%)

160 (23%)

208 (20.2%)

 

 Miscellaneous sarcomas

46 (14%)

76 (11%)

122 (11.9%)

 

 Myxofibrosarcoma

38 (11%)

115 (16%)

153 (14.9%)

 

 Undifferentiated pleomorphic sarcoma

78 (24%)

153 (22%)

231 (22.4%)

 

 Other

38 (11%)

77 (11%)

115 (11.2%)

 

Grade of the tumor

 Grade 1

43 (14%)

101 (15%)

144 (15.1%)

Chi-2 p =0.106

 Grade 2

81 (27%)

227 (35%)

308 (32.4%)

 

 Grade 3

98 (33%)

193 (29%)

291 (30.6%)

 

 Non dimmable

74 (25%)

135 (21%)

209 (22.0%)

 

MDTB before treatment

 No

286 (86%)

642 (92%)

928 (90.2%)

Chi-2 p =0.005

 Yes

45 (14%)

56 (8%)

101 (9.8%)

 

2d surgery performed

 Inside NETSARC

490 (70%)

490 (47.6%)

 

 Outside NETSARC

175 (25%)

175 (17.0%)

 

 Unkwown

33 (5%)

33 (3.2%)

 

Quality of resection

 R0

0 (0%)

599 (86%)

599 (60.4%)

Chi-2 p <0.001

 R1

331(100%)

42 (6%)

373 (37.6%)

 

 Margins not evaluable

0 (0%)

2 (0%)

2 (0%)

 

 Not specified

0 (0%)

55 (8%)

55 (5.3%)

 
  1. The characteristics of RE and no-RE patients were significantly different regarding mean age at diagnosis (p =0.011), tumor sites (trunk wall, upper limb, lower limb, p =0.002), tumor size (p <0.001), tumor depth (p <0.001) and histotype (p=0.001)