Fig. 5

Metformin alters expression of p53 target genes within C4–2 cells. RNA-sequencing was initially performed to identify metformin-regulated genes in the C4–2 cell line. The list of metformin-regulated genes identified by this analysis was then compared to p53 direct target genes characterized by M Fischer et al. [31] using the Venny program. The box inset lists the 41 p53 target genes that are also regulated by metformin