Fig. 4

Correlation of OAS gene family with immune cell infiltration level in BLCA derived from Tumor Immune Estimation Resource (TIMER). The horizontal axis represented the infiltration levels of tumor immune cells. The vertical axis indicated the expression levels of OAS genes. Cor. > 0 indicated the positive correlation of OAS family expression level with tumor immune cell infiltration. Cor. < 0 indicated the negative correlation of OAS family expression level with tumor immune cell infiltration. OAS1 expression had no significant correlation with tumor purity but had significant positive correlations with infiltrating levels of B cells, CD4 + T cells, neutrophils, and dendritic cells in BLCA. OAS2 expression had positive correlations with the infiltrating levels of CD8 + T cells, CD4 + T cells, neutrophils, and dendritic cells, while had negative correlations with tumor purity and the infiltrating level of macrophages in BLCA. OAS3 expression was negatively corelated with tumor purity and had positive correlations with the infiltrating levels of CD8 + T cells, CD4 + T cells, neutrophils, and dendritic cells in BLCA. OASL expression had positive correlations with the infiltrating levels of CD8 + T cells, CD4 + T cells, neutrophils, and dendritic cells, but had negative correlations with tumor purity and macrophage infiltration in BLCA