Fig. 2

Detailed expression levels of OAS gene family in bladder cancer. A Box plot of OAS1, OAS2, OAS3, and OASL expression levels in Sanchez-Carbayo Bladder 2 dataset from Oncomine. Red meant normal tissues, and green meant infiltrating bladder urothelial carcinoma tissues. B Expression characterization of OAS1, OAS2, OAS3, and OASL in GEPIA database. Red and green represented tumor and normal tissues, respectively. C Results of qPCR showing the mRNA levels of OAS family in BLCA tissues and normal bladder tissues. * P < 0.05, ** P < 0.01, *** P < 0.001, n = 7 samples for each group. D Results of Western blotting. Upper, representative electrophoresis bands of Western blots for OAS family protein expressions in BLCA tissues and normal bladder tissues. Lower, statistical results of Western blots. * P < 0.05, ** P < 0.01, *** P < 0.001, n = 7 samples for each group. E Immunohistochemical stains of OAS family proteins in BLCA and normal tissues. Brown colors represented positive staining signals. It is obvious that all the four OAS genes were highly expressed in BLCA tissues compared with the normal bladder tissues