Table 2 Hazard ratios (HRs) for the association of TyG index or TG/HDL-C ratio with CRC risk

TyG index (per 1 unit)

593/1145910

1.27(1.13,1.41)

< 0.001

1.21(1.08,1.36)

0.001

1.19(1.05,1.34)

0.008

Quartiles of TyG index

 Q1 (≤8.19)

111/290016

Ref.

Ref.

Ref.

 Q2 (8.19 ~ 8.58)

131/287327

1.19(0.93,1.53)

0.174

1.13(0.88,1.46)

0.339

1.13(0.88,1.45)

0.351

 Q3 (8.58 ~ 9.06)

170/282736

1.57(1.24,1.99)

< 0.001

1.43(1.12,1.83)

0.004

1.36(1.06,1.76)

0.017

 Q4 (≥9.06)

181/285831

1.65(1.31,2.09)

< 0.001

1.53(1.20,1.93)

0.001

1.50(1.19,1.91)

0.001

 pfor trend

< 0.001

0.001

0.004

TG/HDL-C ratio (per 1 unit)

593/1145910

1.13(1.03,1.23)

0.006

1.12(1.02,1.22)

0.016

1.11(1.01,1.21)

0.027

Quartiles of TG/HDL-C ratio

 Q1 (≤0.57)

113/283296

Ref.

Ref.

Ref.

 Q2 (0.57 ~ 0.85)

153/289407

1.33(1.04,1.69)

0.023

1.33(1.05,1.70)

0.021

1.33(1.04,1.70)

0.023

 Q3 (0.85 ~ 1.36)

162/286268

1.42(1.11,1.80)

0.005

1.37(1.08,1.75)

0.010

1.36(1.07,1.73)

0.013

 Q4 (≥1.36)

165/286939

1.44(1.13,1.82)

0.003

1.40(1.09,1.78)

0.008

1.37(1.07,1.75)

0.013

 pfor trend

0.014

0.032

0.045