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Table 2 All-cause mortality expressed as crude and mutually adjusted hazard ratios (HR) with 95% confidence intervals (CI)

From: Long-term treatment patterns and survival in metastatic breast cancer by intrinsic subtypes – an observational cohort study in Sweden

  

Crude

Mutually adjusted

 

No. of patients/event

HR (95% CI)

P value

P overall

HR (95% CI)

P value

P overall

Tumour subtype

 Lum A

118/83

1.00

  

1.00

  

 Lum B

119/79

1.04 (0.76–1.41)

0.827

 

1.11 (0.80–1.53)

0.534

 

 HER2/ER neg

31/23

1.26 (0.79–2.01)

0.325

 

1.54 (0.93–2.54)

0.096

 

 HER2 Lum

38/19

0.76 (0.46–1.26)

0.292

 

0.73 (0.43–1.25)

0.254

 

 Triple negative

46/42

3.33 (2.27–4.86)

< 0.001

< 0.001

2.95 (1.85–4.70)

< 0.001

< 0.001

Age at metastasis, years

 < 50

50/32

1.00

  

1.00

  

 50–60

46/26

0.90 (0.54–1.51)

0.694

 

1.02 (0.60–1.75)

0.933

 

 60–70

103/77

1.02 (0.67–1.54)

0.935

 

0.99 (0.65–1.53)

0.972

 

 70–80

91/58

0.95 (0.62–1.47)

0.830

 

1.12 (0.71–1.76)

0.619

 

 80+

62/53

2.17 (1.40–3.37)

0.001

< 0.001

3.40 (2.12–5.47)

< 0.001

< 0.001

No. of metastatic sites at M1

 1

158/99

1.00

  

1.00

  

 2

105/76

1.19 (0.88–1.61)

0.247

 

1.39 (1.00–1.92)

0.051

 

 3+

89/71

1.71 (1.26–2.33)

0.001

0.003

1.98 (1.36–2.89)

< 0.001

0.002

Dominating site of disease at M1 dx

 Bone

105/63

1.00

  

1.00

  

 Soft tissue

13/12

2.06 (1.11–3.83)

0.022

 

1.24 (0.64–2.40)

0.533

 

 Visceral

234/171

1.48 (1.11–1.98)

0.007

< 0.001

1.11 (0.78–1.57)

0.560

0.755

Time since primary diagnosis, months

 0–3

80/50

1.00

  

1.00

  

 3–12

21/12

1.04 (0.55–1.95)

0.910

 

1.14 (0.59–2.20)

0.692

 

 12–36

68/53

2.02 (1.37–2.98)

< 0.001

 

1.77 (1.12–2.80)

0.015

 

 36–60

40/29

1.57 (0.99–2.48)

0.054

 

1.59 (0.99–2.54)

0.054

 

 60+

143/102

1.17 (0.83–1.64)

0.376

0.004

1.19 (0.83–1.70)

0.345

0.101

Year at M1 diagnosis

 2009–2011

150/131

1.00

  

1.00

  

 2012–2014

136/84

0.80 (0.60–1.06)

0.124

 

0.82 (0.61–1.10)

0.189

 

 2015–2016

66/31

1.33 (0.88–2.02)

0.178

0.055

1.42 (0.92–2.19)

0.112

0.056