The soluble VCAM-1 level is a potential biomarker predicting severe acute graft versus host disease after allogeneic hematopoietic cell transplantation

Table 2 Cytokine levels at day −7, day 0, day + 7 and day + 14 of HSCT

Cytokine level, ng/ml, mean + SE	Time after HSCT				P-value^a (between day − 7 and day 0)	P-value^a (between day − 7 and day + 7)	P-value^a (between day − 7 and day + 14)	P-value^a (between day + 7 and day + 14)
Cytokine level, ng/ml, mean + SE	day − 7 (n = 30)	day 0 (n = 10)	day + 7 (n = 10)	day + 14 (n = 30)	P-value^a (between day − 7 and day 0)	P-value^a (between day − 7 and day + 7)	P-value^a (between day − 7 and day + 14)	P-value^a (between day + 7 and day + 14)
β2- MG	4429.2 ± 514.4	1223.3 ± 126.6	5960.1 ± 689.7	5651.3 ± 492.5	0.959	0.386	0.028	0.878
sVCAM-1	1039.4 ± 78.7	1223.3 ± 126.6	1194.0 ± 132.2	1614.7 ± 88.8	0.445	0.799	< 0.001	0.007
PF4	406.5 ± 27.9	286.2 ± 61.7	236.2 ± 44.6	313.9 ± 25.7	0.508	0.284	0.006	0.508
TNFSF-14	33.7 ± 3.0	30.4 ± 6.2	21.4 ± 1.3	29.0 ± 2.4	0.858	0.017	0.130	0.047

HSCT Allogeneic hematopoietic stem cell transplantation, β2- MG Beta2-microglobulin, sVCAM-1 Soluble VCAM-1, SE Standard error of the mean
^aWilcoxon signed-rank test

ISSN: 1471-2407