Table 2 Telomere parameters according to CML subgroups
CML patients | Total number of telomeres (mean ± SD) | Total number of telomere aggregates (mean ± SD) | Total intensity (mean ± SD) | Intensity of all signals (mean ± SD) | a/c ratio (mean ± SD) | Nuclear volume (mean ± SD) |
|---|---|---|---|---|---|---|
Chronic phase | 39,45 ± 6,49 | 3,37 ± 1,19 | 414,618,5 ± 235,693,0 | 13,889 ± 2254 | 2,55 ± 0,48 | 191,790 ± 85,724 |
Accelerated/ blast phase | 41,51 ± 5,25 | 4,73 ± 0,92 | 512,852,4 ± 155,272,4 | 14,574 ± 2739 | 6,65 ± 1,97 | 328,714 ± 134,704 |
p.value between chronic and accelerated CML phases | p < 0,001 | p < 0,001 | p < 0,001 | p < 0,001 | p < 0,0001 | p < 0,0001 |