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Table 3 Clinician-rated adverse events of chemotherapy at T2 and T3 according to Common Terminology Criteria for Adverse Events

From: Preventing adverse events of chemotherapy for gastrointestinal cancer by educating patients about the nocebo effect: a randomized-controlled trial

 

T2

T3

EG (n = 38)

CG (n = 35)

Sum

EG (n = 31)

CG (n = 29)

Sum

G1

G2

G3

G1

G2

G3

 

G1

G2

G3

G1

G2

G3

 

Nausea

6

6

0

4

1

0

17

4

2

0

3

0

1

10

Vomiting

0

2

0

3

0

0

19

0

0

0

1

0

1

2

Diarrhoea

4

2

0

7

2

0

15

5

1

0

2

1

0

9

Fatigue

4

6

0

1

1

0

12

4

5

0

3

1

1

14

Headache

0

0

0

0

1

0

1

0

0

0

1

0

0

1

Shortness-of-breath

0

1

0

0

0

0

1

2

0

0

1

0

0

3

Rash

2

0

0

0

0

0

2

1

0

0

0

1

0

2

 

≥1 AE: n = 21

≥1 AE: n = 17

≥1 AE: n = 16

≥1 AE: n = 12

  1. AE adverse events, CG attention control group, EG nocebo education group, T2 10 days after onset of chemotherapy; T3 12 weeks after onset of chemotherapy. G1 Grade 1 “Mild; asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated”, G2 Grade 2 “Moderate; minimal, local or non-invasive intervention indicated; limiting age-appropriate instrumental activities of daily living, G3 Grade 3 “Severe or medically significant but not immediately life-threatening; hospitalization or prolongation of hospitalization indicated; disabling; limiting self-care activities of daily living (defined by the National Institutes of Health, National Cancer Institute, 2009)