Fig. 2

Network diagrams of comparison of different outcomes for patients with advanced or metastatic ESCC. A Comparison on OS and PFS in the first-line treatments. B Comparison of overall response rate and adverse events of 3 or higher in the first-line treatments. C Comparison on OS and PFS in the second-line treatments. D Comparison on overall response rate and adverse events of 3 or higher in the second-line treatments. Each circular node represents a type of treatment. The node size is proportional to the total sample size of the corresponding treatment in all studies. Each line represents a type of head-to-head comparison. The line width is proportional to the number of trials comparing the connected treatments. Abbreviations: ESCC, esophageal squamous cell carcinoma; chemo, chemotherapy