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Fig. 6 | BMC Cancer

Fig. 6

From: ATM kinase inhibitor AZD0156 in combination with irinotecan and 5-fluorouracil in preclinical models of colorectal cancer

Fig. 6

Effect of AZD0156 and SN38 on DNA damage repair in CRC PDX models. Immunofluorescence analysis of P-RAD50 and γH2AX as markers of DDR and ATM activation in CRC026 (A) and CRC102 (B) PDX tumor tissues at end of treatment. DAPI is seen in blue, γH2AX and PRAD-50, respectively, in red. Representative images at 20X magnification. Ratios of γH2AX and P-RAD50 to DAPI as quantified by immunofluorescence in each model; * = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001

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BMC Cancer

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