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Table 1 The 49 human proteasome gene family members (proteasome subunits and proteasome-interacting proteins)

From: Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types

Gene symbol and full name

Subunita

Chromosomeb

Aliasesc

UniProtKB accessionc

Sequence lengthc

(amino acids)

MWc

(Da)

Class I: Proteasome 20S subunit

  PSMA1

Proteasome 20S subunit alpha 1

α6

11p15.2

HC2, NU, PROS30, PSC2

P25786

263

29,556

  PSMA2

Proteasome 20S subunit alpha 2

α2

7p14.1

HC3, PSC3

P25787

234

25,899

  PSMA3

Proteasome 20S subunit alpha 3

α7

14q23.1

HC8, PSC8

P25788

255

28,433

  PSMA4

Proteasome 20S subunit alpha 4

α3

15q25.1

HC9, PSC9

P25789

261

29,484

  PSMA5

Proteasome 20S subunit alpha 5

α5

1p13.3

ZETA

P28066

241

26,411

  PSMA6

Proteasome 20S subunit alpha 6

α1

14q13.2

PROS27

P60900

246

27,399

  PSMA7

Proteasome 20S subunit alpha 7

α4

20q13.33

HSPC

O14818

248

27,887

  PSMA8

Proteasome 20S subunit alpha 8

-

18q11.2

PSMA7L

Q8TAA3

256

28,530

  PSMB1

Proteasome 20S subunit beta 1

β6

6q27

PSC5

P20618

241

26,489

  PSMB2

Proteasome 20S subunit beta 2

β4

1p34.3

HC7-I

P49721

201

22,836

  PSMB3

Proteasome 20S subunit beta 3

β3

17q12

HC10-II, MGC4147

P49720

205

22,949

  PSMB4

Proteasome 20S subunit beta 4

β7

1q21.3

PROS26

P28070

264

29,204

  PSMB5

Proteasome 20S subunit beta 5

β5

14q11.2

LMPX, MB1, X

P28074

263

28,480

  PSMB6

Proteasome 20S subunit beta 6

β1

17p13.2

LMPY, Y

P28072

239

25,358

  PSMB7

Proteasome 20S subunit beta 7

β2

9q33.3

Z

Q99436

277

29,965

  PSMB8

Proteasome 20S subunit beta 8

β5i

6p21.32

LMP7, PSMB5i, RING10, Y2

P28062

276

30,354

  PSMB9

Proteasome 20S subunit beta 9

β1i

6p21.32

LMP2, PSMB6i, RING12

P28065

219

23,264

  PSMB10

Proteasome 20S subunit beta 10

β2i

16q22.1

LMP10, MECL1

P40306

273

28,936

  PSMB11

Proteasome 20S subunit beta 11

β5t

14q11.2

 

A5LHX3

300

32,530

Class II: Proteasome 26S subunit

 

  PSMC1

Proteasome 26S subunit, ATPase 1

Rpt2

14q32.11

S4, p56

P62191

440

49,185

  PSMC2

Proteasome 26S subunit, ATPase 2

Rpt1

7q22.1

MSS1

P35998

433

48,634

  PSMC3IP

PSMC3 Interacting Protein

 

17q21.2

HOP2, TBPIP

Q9P2W1

217

24,906

  PSMC3

Proteasome 26S subunit, ATPase 3

Rpt5

11p11.2

TBP1

P17980

439

49,204

  PSMC4

Proteasome 26S subunit, ATPase 4

Rpt3

19q13.2

TBP-7

P43686

418

47,366

  PSMC5

Proteasome 26S subunit, ATPase 5

Rpt6

17q23.3

SUG1

P62195

406

45,626

  PSMC6

Proteasome 26S subunit, ATPase 6

Rpt4

14q22.1

SUG2

P62333

389

44,173

  PSMD1

Proteasome 26S subunit, non-ATPase 1

Rpn2

2q37.1

S1, P112, Rpn2

Q99460

953

105,836

  PSMD2

Proteasome 26S subunit, non-ATPase 2

Rpn1

3q27.1

TRAP2

Q13200

908

100,200

  PSMD3

Proteasome 26S subunit, non-ATPase 3

Rpn3

17q21.1

S3, P58, Rpn3

O43242

534

60,978

  PSMD4

Proteasome 26S subunit, non-ATPase 4

Rpn10

1q21.3

MCB1

P55036

377

40,737

  PSMD5

Proteasome 26S subunit, non-ATPase 5

-

9q33.2

KIAA0072

Q16401

504

56,196

  PSMD6

Proteasome 26S subunit, non-ATPase 6

Rpn7

3p14.1

KIAA0107, PFAAP4

Q15008

389

45,531

  PSMD7

Proteasome 26S subunit, non-ATPase 7

Rpn8

16q23.1

MOV34L

P51665

324

37,025

  PSMD8

Proteasome 26S subunit, non-ATPase 8

Rpn12

19q13.2

S14, Nin1p, p31, HIP6, HYPF, Rpn12

P48556

350

39,612

  PSMD9

Proteasome 26S subunit, non-ATPase 9

-

12q24.31

p27, Rpn4

O00233

223

24,682

  PSMD10

Proteasome 26S subunit, non-ATPase 10

Gankyrin

Xq22.3

p28

O75832

226

24,428

  PSMD11

Proteasome 26S subunit, non-ATPase 11

Rpn6

17q11.2

S9, p44.5, MGC3844, Rpn6

O00231

422

47,464

  PSMD12

Proteasome 26S subunit, non-ATPase 12

Rpn5

17q24.2

p55, Rpn5

O00232

456

52,904

  PSMD13

Proteasome 26S subunit, non-ATPase 13

Rpn9

11p15.5

p40.5, Rpn9

Q9UNM6

376

42,945

  PSMD14

Proteasome 26S subunit, non-ATPase 14

Rpn11

2q24.2

POH1

O00487

310

34,577

Class III: Proteasome activator

  PSME1

Proteasome activator subunit 1

PA28α

14q12

IFI5111

Q06323

249

28,723

  PSME2

Proteasome activator subunit 2

PA28β

14q12

PA28beta

Q9UL46

239

27,402

  PSME3

Proteasome activator subunit 3

PA28γ

17q21.31

Ki, PA28-gamma, REG-GAMMA, PA28G

P61289

254

29,506

  PSME4

Proteasome activator subunit 4

PA200

2p16.2

KIAA0077

Q14997

1,843

211,334

Class IV: Proteasome inhibitor

  PSMF1

Proteasome inhibitor subunit 1

PI31

20p13

PI31

Q92530

271

29,817

Class V: Proteasome assembly chaperone

  PSMG1

Proteasome Assembly Chaperone 1

 

21q22.2

C21LRP, DSCR2, PAC1

O95456

288

32,854

  PSMG2

Proteasome Assembly Chaperone 2

 

18p11.21

HCCA3, PAC2, TNFSF5IP1

Q969U7

264

29,396

  PSMG3

Proteasome Assembly Chaperone 3

 

7p22.3

C7orf48, PAC3

Q9BT73

122

13,104

  PSMG4

Proteasome Assembly Chaperone 4

 

6p25.2

C6orf86, PAC4

Q5JS54

123

13,775

  1. Data obtained from Gomes AV et al., Genome Reference Consortium Human GRCh38.p12/hg38, UniProtKB