Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types

Larsson, Peter; Pettersson, Daniella; Engqvist, Hanna; Werner Rönnerman, Elisabeth; Forssell-Aronsson, Eva; Kovács, Anikó; Karlsson, Per; Helou, Khalil; Parris, Toshima Z.

doi:10.1186/s12885-022-10079-4

Table 1 The 49 human proteasome gene family members (proteasome subunits and proteasome-interacting proteins)

From: Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types

Gene symbol and full name		Subunit^a	Chromosome^b	Aliases^c	UniProtKB accession^c	Sequence length^c (amino acids)	MW^c (Da)
*Class I: Proteasome 20S subunit*
PSMA1	Proteasome 20S subunit alpha 1	α6	11p15.2	HC2, NU, PROS30, PSC2	P25786	263	29,556
PSMA2	Proteasome 20S subunit alpha 2	α2	7p14.1	HC3, PSC3	P25787	234	25,899
PSMA3	Proteasome 20S subunit alpha 3	α7	14q23.1	HC8, PSC8	P25788	255	28,433
PSMA4	Proteasome 20S subunit alpha 4	α3	15q25.1	HC9, PSC9	P25789	261	29,484
PSMA5	Proteasome 20S subunit alpha 5	α5	1p13.3	ZETA	P28066	241	26,411
PSMA6	Proteasome 20S subunit alpha 6	α1	14q13.2	PROS27	P60900	246	27,399
PSMA7	Proteasome 20S subunit alpha 7	α4	20q13.33	HSPC	O14818	248	27,887
PSMA8	Proteasome 20S subunit alpha 8	-	18q11.2	PSMA7L	Q8TAA3	256	28,530
PSMB1	Proteasome 20S subunit beta 1	β6	6q27	PSC5	P20618	241	26,489
PSMB2	Proteasome 20S subunit beta 2	β4	1p34.3	HC7-I	P49721	201	22,836
PSMB3	Proteasome 20S subunit beta 3	β3	17q12	HC10-II, MGC4147	P49720	205	22,949
PSMB4	Proteasome 20S subunit beta 4	β7	1q21.3	PROS26	P28070	264	29,204
PSMB5	Proteasome 20S subunit beta 5	β5	14q11.2	LMPX, MB1, X	P28074	263	28,480
PSMB6	Proteasome 20S subunit beta 6	β1	17p13.2	LMPY, Y	P28072	239	25,358
PSMB7	Proteasome 20S subunit beta 7	β2	9q33.3	Z	Q99436	277	29,965
PSMB8	Proteasome 20S subunit beta 8	β5i	6p21.32	LMP7, PSMB5i, RING10, Y2	P28062	276	30,354
PSMB9	Proteasome 20S subunit beta 9	β1i	6p21.32	LMP2, PSMB6i, RING12	P28065	219	23,264
PSMB10	Proteasome 20S subunit beta 10	β2i	16q22.1	LMP10, MECL1	P40306	273	28,936
PSMB11	Proteasome 20S subunit beta 11	β5t	14q11.2		A5LHX3	300	32,530
*Class II: Proteasome 26S subunit*
PSMC1	Proteasome 26S subunit, ATPase 1	Rpt2	14q32.11	S4, p56	P62191	440	49,185
PSMC2	Proteasome 26S subunit, ATPase 2	Rpt1	7q22.1	MSS1	P35998	433	48,634
PSMC3IP	PSMC3 Interacting Protein		17q21.2	HOP2, TBPIP	Q9P2W1	217	24,906
PSMC3	Proteasome 26S subunit, ATPase 3	Rpt5	11p11.2	TBP1	P17980	439	49,204
PSMC4	Proteasome 26S subunit, ATPase 4	Rpt3	19q13.2	TBP-7	P43686	418	47,366
PSMC5	Proteasome 26S subunit, ATPase 5	Rpt6	17q23.3	SUG1	P62195	406	45,626
PSMC6	Proteasome 26S subunit, ATPase 6	Rpt4	14q22.1	SUG2	P62333	389	44,173
PSMD1	Proteasome 26S subunit, non-ATPase 1	Rpn2	2q37.1	S1, P112, Rpn2	Q99460	953	105,836
PSMD2	Proteasome 26S subunit, non-ATPase 2	Rpn1	3q27.1	TRAP2	Q13200	908	100,200
PSMD3	Proteasome 26S subunit, non-ATPase 3	Rpn3	17q21.1	S3, P58, Rpn3	O43242	534	60,978
PSMD4	Proteasome 26S subunit, non-ATPase 4	Rpn10	1q21.3	MCB1	P55036	377	40,737
PSMD5	Proteasome 26S subunit, non-ATPase 5	-	9q33.2	KIAA0072	Q16401	504	56,196
PSMD6	Proteasome 26S subunit, non-ATPase 6	Rpn7	3p14.1	KIAA0107, PFAAP4	Q15008	389	45,531
PSMD7	Proteasome 26S subunit, non-ATPase 7	Rpn8	16q23.1	MOV34L	P51665	324	37,025
PSMD8	Proteasome 26S subunit, non-ATPase 8	Rpn12	19q13.2	S14, Nin1p, p31, HIP6, HYPF, Rpn12	P48556	350	39,612
PSMD9	Proteasome 26S subunit, non-ATPase 9	-	12q24.31	p27, Rpn4	O00233	223	24,682
PSMD10	Proteasome 26S subunit, non-ATPase 10	Gankyrin	Xq22.3	p28	O75832	226	24,428
PSMD11	Proteasome 26S subunit, non-ATPase 11	Rpn6	17q11.2	S9, p44.5, MGC3844, Rpn6	O00231	422	47,464
PSMD12	Proteasome 26S subunit, non-ATPase 12	Rpn5	17q24.2	p55, Rpn5	O00232	456	52,904
PSMD13	Proteasome 26S subunit, non-ATPase 13	Rpn9	11p15.5	p40.5, Rpn9	Q9UNM6	376	42,945
PSMD14	Proteasome 26S subunit, non-ATPase 14	Rpn11	2q24.2	POH1	O00487	310	34,577
*Class III: Proteasome activator*
PSME1	Proteasome activator subunit 1	PA28α	14q12	IFI5111	Q06323	249	28,723
PSME2	Proteasome activator subunit 2	PA28β	14q12	PA28beta	Q9UL46	239	27,402
PSME3	Proteasome activator subunit 3	PA28γ	17q21.31	Ki, PA28-gamma, REG-GAMMA, PA28G	P61289	254	29,506
PSME4	Proteasome activator subunit 4	PA200	2p16.2	KIAA0077	Q14997	1,843	211,334
*Class IV: Proteasome inhibitor*
PSMF1	Proteasome inhibitor subunit 1	PI31	20p13	PI31	Q92530	271	29,817
*Class V: Proteasome assembly chaperone*
PSMG1	Proteasome Assembly Chaperone 1		21q22.2	C21LRP, DSCR2, PAC1	O95456	288	32,854
PSMG2	Proteasome Assembly Chaperone 2		18p11.21	HCCA3, PAC2, TNFSF5IP1	Q969U7	264	29,396
PSMG3	Proteasome Assembly Chaperone 3		7p22.3	C7orf48, PAC3	Q9BT73	122	13,104
PSMG4	Proteasome Assembly Chaperone 4		6p25.2	C6orf86, PAC4	Q5JS54	123	13,775

Data obtained from ^aGomes AV et al., ^bGenome Reference Consortium Human GRCh38.p12/hg38, ^cUniProtKB

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ISSN: 1471-2407

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