Skip to main content

Table 1 The 49 human proteasome gene family members (proteasome subunits and proteasome-interacting proteins)

From: Pan-cancer analysis of genomic and transcriptomic data reveals the prognostic relevance of human proteasome genes in different cancer types

Gene symbol and full name Subunita Chromosomeb Aliasesc UniProtKB accessionc Sequence lengthc
(amino acids)
MWc
(Da)
Class I: Proteasome 20S subunit
  PSMA1 Proteasome 20S subunit alpha 1 α6 11p15.2 HC2, NU, PROS30, PSC2 P25786 263 29,556
  PSMA2 Proteasome 20S subunit alpha 2 α2 7p14.1 HC3, PSC3 P25787 234 25,899
  PSMA3 Proteasome 20S subunit alpha 3 α7 14q23.1 HC8, PSC8 P25788 255 28,433
  PSMA4 Proteasome 20S subunit alpha 4 α3 15q25.1 HC9, PSC9 P25789 261 29,484
  PSMA5 Proteasome 20S subunit alpha 5 α5 1p13.3 ZETA P28066 241 26,411
  PSMA6 Proteasome 20S subunit alpha 6 α1 14q13.2 PROS27 P60900 246 27,399
  PSMA7 Proteasome 20S subunit alpha 7 α4 20q13.33 HSPC O14818 248 27,887
  PSMA8 Proteasome 20S subunit alpha 8 - 18q11.2 PSMA7L Q8TAA3 256 28,530
  PSMB1 Proteasome 20S subunit beta 1 β6 6q27 PSC5 P20618 241 26,489
  PSMB2 Proteasome 20S subunit beta 2 β4 1p34.3 HC7-I P49721 201 22,836
  PSMB3 Proteasome 20S subunit beta 3 β3 17q12 HC10-II, MGC4147 P49720 205 22,949
  PSMB4 Proteasome 20S subunit beta 4 β7 1q21.3 PROS26 P28070 264 29,204
  PSMB5 Proteasome 20S subunit beta 5 β5 14q11.2 LMPX, MB1, X P28074 263 28,480
  PSMB6 Proteasome 20S subunit beta 6 β1 17p13.2 LMPY, Y P28072 239 25,358
  PSMB7 Proteasome 20S subunit beta 7 β2 9q33.3 Z Q99436 277 29,965
  PSMB8 Proteasome 20S subunit beta 8 β5i 6p21.32 LMP7, PSMB5i, RING10, Y2 P28062 276 30,354
  PSMB9 Proteasome 20S subunit beta 9 β1i 6p21.32 LMP2, PSMB6i, RING12 P28065 219 23,264
  PSMB10 Proteasome 20S subunit beta 10 β2i 16q22.1 LMP10, MECL1 P40306 273 28,936
  PSMB11 Proteasome 20S subunit beta 11 β5t 14q11.2   A5LHX3 300 32,530
Class II: Proteasome 26S subunit  
  PSMC1 Proteasome 26S subunit, ATPase 1 Rpt2 14q32.11 S4, p56 P62191 440 49,185
  PSMC2 Proteasome 26S subunit, ATPase 2 Rpt1 7q22.1 MSS1 P35998 433 48,634
  PSMC3IP PSMC3 Interacting Protein   17q21.2 HOP2, TBPIP Q9P2W1 217 24,906
  PSMC3 Proteasome 26S subunit, ATPase 3 Rpt5 11p11.2 TBP1 P17980 439 49,204
  PSMC4 Proteasome 26S subunit, ATPase 4 Rpt3 19q13.2 TBP-7 P43686 418 47,366
  PSMC5 Proteasome 26S subunit, ATPase 5 Rpt6 17q23.3 SUG1 P62195 406 45,626
  PSMC6 Proteasome 26S subunit, ATPase 6 Rpt4 14q22.1 SUG2 P62333 389 44,173
  PSMD1 Proteasome 26S subunit, non-ATPase 1 Rpn2 2q37.1 S1, P112, Rpn2 Q99460 953 105,836
  PSMD2 Proteasome 26S subunit, non-ATPase 2 Rpn1 3q27.1 TRAP2 Q13200 908 100,200
  PSMD3 Proteasome 26S subunit, non-ATPase 3 Rpn3 17q21.1 S3, P58, Rpn3 O43242 534 60,978
  PSMD4 Proteasome 26S subunit, non-ATPase 4 Rpn10 1q21.3 MCB1 P55036 377 40,737
  PSMD5 Proteasome 26S subunit, non-ATPase 5 - 9q33.2 KIAA0072 Q16401 504 56,196
  PSMD6 Proteasome 26S subunit, non-ATPase 6 Rpn7 3p14.1 KIAA0107, PFAAP4 Q15008 389 45,531
  PSMD7 Proteasome 26S subunit, non-ATPase 7 Rpn8 16q23.1 MOV34L P51665 324 37,025
  PSMD8 Proteasome 26S subunit, non-ATPase 8 Rpn12 19q13.2 S14, Nin1p, p31, HIP6, HYPF, Rpn12 P48556 350 39,612
  PSMD9 Proteasome 26S subunit, non-ATPase 9 - 12q24.31 p27, Rpn4 O00233 223 24,682
  PSMD10 Proteasome 26S subunit, non-ATPase 10 Gankyrin Xq22.3 p28 O75832 226 24,428
  PSMD11 Proteasome 26S subunit, non-ATPase 11 Rpn6 17q11.2 S9, p44.5, MGC3844, Rpn6 O00231 422 47,464
  PSMD12 Proteasome 26S subunit, non-ATPase 12 Rpn5 17q24.2 p55, Rpn5 O00232 456 52,904
  PSMD13 Proteasome 26S subunit, non-ATPase 13 Rpn9 11p15.5 p40.5, Rpn9 Q9UNM6 376 42,945
  PSMD14 Proteasome 26S subunit, non-ATPase 14 Rpn11 2q24.2 POH1 O00487 310 34,577
Class III: Proteasome activator
  PSME1 Proteasome activator subunit 1 PA28α 14q12 IFI5111 Q06323 249 28,723
  PSME2 Proteasome activator subunit 2 PA28β 14q12 PA28beta Q9UL46 239 27,402
  PSME3 Proteasome activator subunit 3 PA28γ 17q21.31 Ki, PA28-gamma, REG-GAMMA, PA28G P61289 254 29,506
  PSME4 Proteasome activator subunit 4 PA200 2p16.2 KIAA0077 Q14997 1,843 211,334
Class IV: Proteasome inhibitor
  PSMF1 Proteasome inhibitor subunit 1 PI31 20p13 PI31 Q92530 271 29,817
Class V: Proteasome assembly chaperone
  PSMG1 Proteasome Assembly Chaperone 1   21q22.2 C21LRP, DSCR2, PAC1 O95456 288 32,854
  PSMG2 Proteasome Assembly Chaperone 2   18p11.21 HCCA3, PAC2, TNFSF5IP1 Q969U7 264 29,396
  PSMG3 Proteasome Assembly Chaperone 3   7p22.3 C7orf48, PAC3 Q9BT73 122 13,104
  PSMG4 Proteasome Assembly Chaperone 4   6p25.2 C6orf86, PAC4 Q5JS54 123 13,775
  1. Data obtained from Gomes AV et al., Genome Reference Consortium Human GRCh38.p12/hg38, UniProtKB