Fig. 6

The prognostic relevance of PSM gene expression in different cancer types using overall survival (OS) and progression-free interval (PFI) as clinical endpoints in multivariable Cox regression analysis (adjusted for age and/or tumor grade). A-B Dot plots displaying the –log10(p-value) for the multivariable Cox regression analysis between PSM gene expression and OS (A) and PFI (B). Blue dots indicate a hazardous role for PSM gene expression, while red dots indicate a protective role. NS = not significant (P > 0.05). Dot sizes denote –log10(p-value); P < 0.001 is shown as –log10(p-value) = 3. Due to a lack of clinical data, PFI could not be performed for acute myeloid leukemia (LAML). C-D Bar charts illustrating the number of cancer types associated with different expression levels for each prognostic PSM gene. PSM gene expression (high [blue bars, higher than median expression] and low [yellow bars, lower than median expression]) associated with OS (C) and PFI (D) in different cancer types