Table 4 Multivariable analysis
Model 1: Forward linear regression taking the Cog PCI score as the dependent variable | |||||
Variable | UB | SB | p | 95% Confidence Interval | |
Anxiety | -1.06 | -0.39 | < 0.001 | -1.53 | -0.60 |
Diabetes (yes vs no*) | -8.94 | -0.19 | 0.034 | -17.17 | -0.71 |
*Reference group; Variables entered in Model 1: Diabetes, ISI score, VAS score, depression, anxiety | |||||
Model 2: Forward linear regression taking the Cog PCA score as the dependent variable | |||||
Variable | UB | SB | p | 95% Confidence Interval | |
University education level compared to primary* | 2.75 | 0.23 | 0.017 | 0.50 | 5.01 |
*Reference group; Variables entered in Model 2: VAS score, education | |||||
Model 3: Forward linear regression taking the Cog OTH score as the dependent variable | |||||
Variable | UB | SB | p | 95% Confidence Interval | |
Depression | -0.25 | -0.36 | < 0.001 | -0.37 | -0.13 |
Type of chemotherapy (adjuvant treatment vs palliative regimen*) | 1.65 | 0.24 | 0.007 | 0.45 | 2.84 |
*Reference group; Variables entered in Model 3: Type of chemotherapy, depression, anxiety, doxorubicin intake, CLOCK | |||||
Model 4: Forward linear regression taking the Cog QOL score as the dependent variable | |||||
Variable | UB | SB | p | 95% Confidence Interval | |
Depression | -0.24 | -0.23 | 0.012 | -0.42 | -0.05 |
Type of chemotherapy (adjuvant treatment vs palliative regimen*) | 3.21 | 0.31 | < 0.001 | 1.54 | 4.87 |
Insomnia severity (ISI score) | -0.17 | -0.25 | 0.005 | -0.28 | -0.05 |
OPRM1 (AG vs AA*) | 2.05 | 0.17 | 0.038 | 0.11 | 3.98 |
*Reference group; Variables entered in Model 4: Metastasis, Type of chemotherapy, OPRM1 SNP, PSQI score, ISI score, cycle number, VAS score, anxiety, depression, marital status, BMI | |||||
Model 5: Forward linear regression taking the total FACT-Cog score as the dependent variable | |||||
Variable | UB | SB | p | 95% Confidence Interval | |
Depression | -1.91 | -0.38 | < 0.001 | -2.77 | -1.04 |
Type of chemotherapy (neo-adjuvant treatment vs palliative regimen*) | -13.80 | -0.25 | 0.005 | -23.41 | -4.19 |
*Reference group; Variables entered in Model 5: Type of chemotherapy, PSQI score, ISI score, cycle number, VAS score, anxiety, depression, diabetes | |||||