Fig. 3

Comparison of Anx expression between healthy and malignant tissue. Data of Anx mRNA expression in healthy tumour-adjacent and malignant tissue was taken from the Gene Expression Omnibus (GEO) database. The expression levels of all 12 members of the Anx family were added and compared between samples from the indicated cancer entities. The number of available patient samples is indicated in the corner of each graph. Except for breast cancer data (B, C), all datasets provided paired data for each patient. Microarray expression data is normalised using the MAS5 method (A - D) or the RMA method (E – H). Significance was calculated using a paired (unpaired for breast cancer) two-tailed t-test (**** p<0.0001, *** p<0.001, ** p<0.01, * p<0.05, ns not significant).