Table 1 Exploratory objectives of ABNL-MARRO 001

 • To investigate genetic biomarkers of response in MDS/MPN

 • To characterize molecular responses to individual treatments

 • To evaluate synergistic effects of hypomethylation by ASTX727 and specific pathway blockade by study compounds

 • To explore the use of automated quantification of spleen volume from CT exams as a measure of clinical benefit

 • To test and/or validate diagnostic algorithms and prognostic indices for MDS/MPN patients

 • To investigate the correlation of patient reported outcomes with disease severity and/or treatment response