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Table 2 Clinicopathological features and treatment of thyroid cancer patients followed  breast cancer and thyroid cancer alone patients (2nd cohort)

From: The co-occurrence of both breast- and differentiated thyroid cancer: incidence, association and clinical implications for daily practice

Variables

TC‐BC (median (IQR)/%)

TC alone (median (IQR)/%)

p‐value

No. of patients

355

12015

 

TC clinical characteristics

  Age at TC diagnosis

51 (42-61)

50 (38-64)

0.3

  Female

353 (99.4)

8593 (71.5)

<0.001

  Tumor size in mm

28 (18-39)

19 (9-34)

0.2

  Tumor site

   

      Left

4 (1.1)

737 (6.1)

< 0.001

      Right

5 (1.4)

1018 (8.5) 

      Isthmus

2 (0.6)

103 (0.9)

      Ectopic

0

15 (0.1)

      Both sites

3 (0.8)

451 (3.7)

      Unknown

341 (96.1)

9623 (80.1) 

  TNM stage 

   

      I

186 (52.4)

7017 (58.4)

< 0.001

      II

89 (25.0)

1769 (14.7)

< 0.001

      III

55 (15.5)

1715 (14.3)

 

      IV

6 (1.7)

221 (1.8)

      IVa

10 (2.8)

667 (5.6)

      IVb

3 (0.8)

107 (0.9)

      IVc

2 (0.6)

312 (2.6)

      M

1 (0.3)

40 (0.3)

      Unknown

3 (0.8)

168 (1.4)

  TC surgery2

352 (99.2) 

11351 (94.5) 

< 0.001

      Thyroidectomy

287 (80.8)

8954 (74.5)

 

      Hemithyroidectomy

65 (18.3)

2379 (19.8)

      Isthmusectomy

0

18 (0.1)

 

  TC radioactive iodine

252 (71.4) 

8068 (67.1)

0.1

  TC radiation therapy

6 (1.7)

280 (2.3)

0.7

BC clinical characteristics

  Age at BC diagnosis

61 (52-70)

  

  Tumor size in mm

15 (11-25)

  

  TNM stage 

331 (78.3)

  

       0

53 (15.0)

  

       I

149 (42.0)

  

       II

99 (27.9)

  

       III

32 (9.0)

  

       IV 

13 (3.7)

  

       M

1 (0.3)

  

       Unknown

8 (2.3)

  

  ER-positvity

211 (84.71

  

  PR-positivity

169 (68.41)

  

  HER2-positivity

34 (14.61)

  
  1. 1 Missings substracted
  2. 2 Missing patients