Characteristics | Univariate analysis | P value | Multivariate analysis | P value |
---|---|---|---|---|
HR (95% CI) | HR (95% CI) | |||
Age | ||||
<50 | Reference | Reference | ||
50 ~ 59 | 0.352(0.297 ~ 0.417) | < 0.001 | 1.279(1.065 ~ 1.535) | < 0.001 |
60 ~ 69 | 0.589(0.541 ~ 0.641) | < 0.001 | 1.482(1.245 ~ 1.763) | 0.008 |
≥ 70 | 0.724(0.681 ~ 0.77) | < 0.001 | 1.999(1.681 ~ 2.377) | < 0.001 |
Sex | ||||
Female | Reference | Reference | ||
Male | 0.602(0.57 ~ 0.637) | < 0.001 | 1.368(1.292 ~ 1.448) | < 0.001 |
TumorType | ||||
Adenocarcinoma | Reference | Reference | ||
Squamous cell carcinoma | 4.559(3.661 ~ 5.678) | < 0.001 | 1.13(1.06 ~ 1.205) | < 0.001 |
Adenosquamous carcinoma | 7.951(6.371 ~ 9.924) | < 0.001 | 1.227(1.051 ~ 1.432) | < 0.001 |
Large cell carcinoma | 8.139(6.258 ~ 10.586) | < 0.001 | 1.494(1.263 ~ 1.767) | < 0.001 |
Others | 9.402(7.228 ~ 12.231) | < 0.001 | 0.312(0.248 ~ 0.392) | < 0.001 |
Laterality | ||||
Left | Reference | |||
Right | 1.042(0.986 ~ 1.102) | 0.147 | ||
Primary site | ||||
Upper lobe | Reference | Reference | ||
Middle lobe | 0.766(0.654 ~ 0.896) | < 0.001 | 1.016(0.892 ~ 1.158) | < 0.001 |
Lower lobe | 0.593(0.487 ~ 0.722) | < 0.001 | 1.122(1.056 ~ 1.192) | 0.807 |
Others | 0.802(0.683 ~ 0.942) | < 0.001 | 1.156(0.983 ~ 1.358) | < 0.001 |
Grade | ||||
Unknown | Reference | Reference | ||
I | 0.477(0.377 ~ 0.604) | < 0.001 | 0.622(0.533 ~ 0.725) | < 0.001 |
II | 0.269(0.215 ~ 0.336) | < 0.001 | 1.142(1.001 ~ 1.303) | < 0.001 |
III | 0.7(0.569 ~ 0.862) | < 0.001 | 1.488(1.304 ~ 1.698) | < 0.001 |
IV | 1.106(0.898 ~ 1.361) | < 0.001 | 1.261(0.982 ~ 1.618) | < 0.001 |
Stage | ||||
IA | Reference | Reference | ||
IB | 0.281(0.259 ~ 0.304) | < 0.001 | 1.47(1.243 ~ 1.739) | < 0.001 |
IIA | 0.539(0.498 ~ 0.584) | < 0.001 | 1.977(1.641 ~ 2.382) | < 0.001 |
IIB | 0.896(0.823 ~ 0.975) | < 0.001 | 2.088(1.596 ~ 2.733) | < 0.001 |
Surgery | ||||
Sub-lobectomy | Reference | Reference | ||
Lobectomy | 0.399(0.292 ~ 0.546) | < 0.001 | 0.763(0.699 ~ 0.832) | < 0.001 |
Pneumonectomy | 0.371(0.273 ~ 0.505) | < 0.001 | 0.982(0.865 ~ 1.114) | < 0.001 |
Palliative | 0.716(0.52 ~ 0.984) | < 0.001 | 1.561(1.131 ~ 2.154) | 0.775 |
Chemotherapy | ||||
No/unknown | Reference | Reference | ||
Yes | 0.568(0.534 ~ 0.605) | < 0.001 | 0.858(0.795 ~ 0.925) | < 0.001 |
Nodes | ||||
0 | Reference | Reference | ||
1 ~ 9 | 1.092(0.919 ~ 1.297) | < 0.001 | 0.628(0.566 ~ 0.698) | < 0.001 |
10 ~ 19 | 0.817(0.698 ~ 0.956) | < 0.001 | 0.533(0.475 ~ 0.599) | < 0.001 |
20 ~ 29 | 0.793(0.675 ~ 0.931) | < 0.001 | 0.449(0.387 ~ 0.521) | < 0.001 |
≥ 30 | 0.772(0.641 ~ 0.93) | < 0.001 | 0.542(0.451 ~ 0.652) | < 0.001 |
Positive | ||||
No/unknown | Reference | Reference | ||
Yes | 0.457(0.426 ~ 0.491) | < 0.001 | 1.339(1.165 ~ 1.539) | < 0.001 |
TumorSize | ||||
≤ 9 mm | Reference | Reference | ||
10–19 mm | 0.262(0.217 ~ 0.317) | < 0.001 | 1.289(1.058 ~ 1.572) | < 0.001 |
20–29 mm | 0.392(0.364 ~ 0.421) | < 0.001 | 1.662(1.363 ~ 2.027) | 0.012 |
≥ 30 mm | 0.57(0.533 ~ 0.61) | < 0.001 | 2.207(1.797 ~ 2.712) | < 0.001 |
Number | ||||
1 | Reference | |||
≥ 2 | 0.93(0.864 ~ 1.001) | 0.052 |