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Table 2 Selected factors in the training cohort for building the model by univariate and multivariate Cox regression analysis

From: Development and validation of a prognostic nomogram for early stage non-small cell lung cancer: a study based on the SEER database and a Chinese cohort

Characteristics Univariate analysis P value Multivariate analysis P value
HR (95% CI) HR (95% CI)
Age
 <50 Reference   Reference  
 50 ~ 59 0.352(0.297 ~ 0.417)  < 0.001 1.279(1.065 ~ 1.535)  < 0.001
 60 ~ 69 0.589(0.541 ~ 0.641)  < 0.001 1.482(1.245 ~ 1.763) 0.008
 ≥ 70 0.724(0.681 ~ 0.77)  < 0.001 1.999(1.681 ~ 2.377)  < 0.001
Sex
 Female Reference   Reference  
 Male 0.602(0.57 ~ 0.637)  < 0.001 1.368(1.292 ~ 1.448)  < 0.001
TumorType
 Adenocarcinoma Reference   Reference  
 Squamous cell carcinoma 4.559(3.661 ~ 5.678)  < 0.001 1.13(1.06 ~ 1.205)  < 0.001
 Adenosquamous carcinoma 7.951(6.371 ~ 9.924)  < 0.001 1.227(1.051 ~ 1.432)  < 0.001
 Large cell carcinoma 8.139(6.258 ~ 10.586)  < 0.001 1.494(1.263 ~ 1.767)  < 0.001
 Others 9.402(7.228 ~ 12.231)  < 0.001 0.312(0.248 ~ 0.392)  < 0.001
Laterality
 Left Reference    
 Right 1.042(0.986 ~ 1.102) 0.147   
Primary site
 Upper lobe Reference   Reference  
 Middle lobe 0.766(0.654 ~ 0.896)  < 0.001 1.016(0.892 ~ 1.158)  < 0.001
 Lower lobe 0.593(0.487 ~ 0.722)  < 0.001 1.122(1.056 ~ 1.192) 0.807
 Others 0.802(0.683 ~ 0.942)  < 0.001 1.156(0.983 ~ 1.358)  < 0.001
Grade
 Unknown Reference   Reference  
 I 0.477(0.377 ~ 0.604)  < 0.001 0.622(0.533 ~ 0.725)  < 0.001
 II 0.269(0.215 ~ 0.336)  < 0.001 1.142(1.001 ~ 1.303)  < 0.001
 III 0.7(0.569 ~ 0.862)  < 0.001 1.488(1.304 ~ 1.698)  < 0.001
 IV 1.106(0.898 ~ 1.361)  < 0.001 1.261(0.982 ~ 1.618)  < 0.001
Stage
 IA Reference   Reference  
 IB 0.281(0.259 ~ 0.304)  < 0.001 1.47(1.243 ~ 1.739)  < 0.001
 IIA 0.539(0.498 ~ 0.584)  < 0.001 1.977(1.641 ~ 2.382)  < 0.001
 IIB 0.896(0.823 ~ 0.975)  < 0.001 2.088(1.596 ~ 2.733)  < 0.001
Surgery
 Sub-lobectomy Reference   Reference  
 Lobectomy 0.399(0.292 ~ 0.546)  < 0.001 0.763(0.699 ~ 0.832)  < 0.001
 Pneumonectomy 0.371(0.273 ~ 0.505)  < 0.001 0.982(0.865 ~ 1.114)  < 0.001
 Palliative 0.716(0.52 ~ 0.984)  < 0.001 1.561(1.131 ~ 2.154) 0.775
Chemotherapy
 No/unknown Reference   Reference  
 Yes 0.568(0.534 ~ 0.605)  < 0.001 0.858(0.795 ~ 0.925)  < 0.001
Nodes
 0 Reference   Reference  
 1 ~ 9 1.092(0.919 ~ 1.297)  < 0.001 0.628(0.566 ~ 0.698)  < 0.001
 10 ~ 19 0.817(0.698 ~ 0.956)  < 0.001 0.533(0.475 ~ 0.599)  < 0.001
 20 ~ 29 0.793(0.675 ~ 0.931)  < 0.001 0.449(0.387 ~ 0.521)  < 0.001
 ≥ 30 0.772(0.641 ~ 0.93)  < 0.001 0.542(0.451 ~ 0.652)  < 0.001
Positive
 No/unknown Reference   Reference  
 Yes 0.457(0.426 ~ 0.491)  < 0.001 1.339(1.165 ~ 1.539)  < 0.001
TumorSize
 ≤ 9 mm Reference   Reference  
 10–19 mm 0.262(0.217 ~ 0.317)  < 0.001 1.289(1.058 ~ 1.572)  < 0.001
 20–29 mm 0.392(0.364 ~ 0.421)  < 0.001 1.662(1.363 ~ 2.027) 0.012
 ≥ 30 mm 0.57(0.533 ~ 0.61)  < 0.001 2.207(1.797 ~ 2.712)  < 0.001
Number
 1 Reference    
 ≥ 2 0.93(0.864 ~ 1.001) 0.052