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Table 1 Demographics and clinicopathologic characteristics of the training and external validation cohor

From: Development and validation of a prognostic nomogram for early stage non-small cell lung cancer: a study based on the SEER database and a Chinese cohort

  Training cohort Internal validation cohort External validation cohort
Characteristics (N = 18,805,n(%) (N = 8136), n(%) (N = 505), n(%)
Age
 <50 1003 (5.33) 399 (4.90) 119 (23.56)
 50 ~ 59 3252 (17.29) 1480 (18.19) 129 (25.54)
 60 ~ 69 6789 (36.10) 2857 (35.12) 166 (32.87)
 ≥ 70 7761 (41.27) 3400 (41.79) 91 (18.02)
Sex
 Female 10505 (55.86) 4454 (54.74) 327 (64.75)
 Male 8300 (44.14) 3682 (45.26) 178 (35.25)
PrimarySite
 Upper 10973 (58.35) 4737 (58.22) 308 (60.99)
 Middle 1159 (6.16) 489 (6.01) 44 (8.71)
 Lower 6172 (32.82) 2710 (33.31) 140 (27.72)
 Other 501 (2.66) 200 (2.46) 13 (2.57)
TumorType
 Adenocarcinoma 12034 (63.99) 5175 (63.61) 473 (93.66)
 Squamous cell carcinoma 4482 (23.83) 1957 (24.05) 25 (4.95)
 Adenosquamous carcinoma 418 (2.22) 200 (2.46) 1 (0.20)
 Large cell carcinoma 374 (1.99) 161 (1.98) 3 (0.59)
 Others 1497 (7.96) 643 (7.90) 3 (0.59)
Grade
 Unknown 1536 (8.17) 652 (8.01) 4 (0.79)
 Grade I 3861 (20.53) 1664 (20.45) 307 (60.79)
 Grade II 7880 (41.90) 3468 (42.63) 97 (19.21)
 Grade III 5288 (28.12) 2266 (27.85) 60 (11.88)
 Grade IV 240 (1.28) 86 (1.06) 37 (7.33)
Laterality
 Left 7800 (41.48) 3280 (40.31) 213 (42.18)
 Right 11005 (58.52) 4856 (59.69) 292 (57.82)
Stage
 IA 8999 (47.85) 3932 (48.33) 445 (88.12)
 IB 5053 (26.87) 2173 (26.71) 42 (8.32)
 IIA 2524 (13.42) 1119 (13.75) 10 (1.98)
 IIB 2229 (11.85) 912 (11.21) 8 (1.58)
T
 T1 9696 (51.56) 4234 (52.04) 416 (82.38)
 T2 7185 (38.21) 3126 (38.42) 61 (12.08)
 T3 1924 (10.23) 776 (9.54) 28 (5.54)
N
 N0 16822 (89.45) 7249 (89.10) 490 (97.03)
 N1 1983 (10.55) 887 (10.90) 15 (2.97)
Surgery
 Sub-lobectomy 3375 (17.95) 1467 (18.03) 358 (70.89)
 Lobectomy 14256 (75.81) 6151 (75.60) 145 (28.71)
 Pneumonectomy 1110 (5.90) 479 (5.89) 1 (0.20)
 Palliative 64 (0.34) 39 (0.48) 1 (0.20)
Chemotherapy
 No/Unknow 15519 (82.53) 6692 (82.25) 464 (91.88)
 Yes 3286 (17.47) 1444 (17.75) 41 (8.12)
Nodes
 0 1663 (8.84) 747 (9.18) 97 (19.21)
 1 ~ 9 9743 (51.81) 4198 (51.60) 206 (40.79)
 10 ~ 19 5380 (28.61) 2287 (28.11) 140 (27.72)
 20 ~ 29 1479 (7.86) 609 (7.49) 49 (9.70)
 ≥ 30 540 (2.87) 295 (3.63) 13 (2.57)
Positive
 No/Unknow 16876 (89.74) 7275 (89.42) 493 (97.62)
 Yes 1929 (10.26) 861 (10.58) 12 (2.38)
TumorSize
 ≤ 9 mm 791 (4.21) 336 (4.13) 233 (46.14)
 10 ~ 19 mm 5707 (30.35) 2490 (30.60) 182 (36.04)
 20 ~ 29 mm 5342 (28.41) 2294 (28.20) 51 (10.10)
 ≥ 30 mm 6965 (37.04) 3016 (37.07) 39 (7.72)
Number
 1 16,053 (85.37) 6968 (85.64) 467 (92.48)
 ≥ 2 2752 (14.63) 1168 (14.36) 38 (7.52)