The impact of age on rectal cancer treatment, complications and survival

BMC Cancer

Table 5 Factors associated with postoperative complications, based on Clavien-Dindo scores, in 431 patients treated for Stages I-III rectal cancer with a major resection with curative intent (R0 and R1)

Factor	Unadjusted odds ratio (95% CI)	p value	Adjusted odds ratio (95% CI)	p value
Age (years)
<65	1 (reference)		1 (reference)
65 - 79	2.07 (1.36 to 3.14)	0.001	1.91 (1.22 to 2.99)	0.005
80 +	2.22 (1.26 to 3.90)	0.005	2.20 (1.15 to 4.22)	0.017
Female sex	0.83 (0.57 to 1.19)	0.31	0.96 (0.65 to 1.41)	0.82
Calendar-year
1980-1989	1 (reference)		1 (reference)
1990-1999	0.46 (0.27 to 0.79)	0.004	0.49 (0.28 to 0.87)	0.014
2000-2009	0.34 (0.20 to 0.58)	<0.001	0.56 (0.30 to 1.02)	0.059
2010-2016	0.44 (0.26 to 0.75)	0.003	1.12 (0.56 to 2.25)	0.75
Preoperative radiochemotherapy	1.11 (0.68 to 1.80)	0.68	0.98 (0.56 to 1.71)	0.93
ASA score
1–2	1 (reference)		1 (reference)
3	1.80 (1.23 to 2.65)	0.003	1.74 (1.14 to 2.68)	0.011
4	20.99 (1.05 to 421)	0.047	11.04 (0.70 to 173)	0.087
Treatment
AR	1 (reference)		1 (reference)
APR	2.05 (1.33 to 3.14)	0.001	1.25 (0.77 to 2.00)	0.37
Hartmann’s procedure	1.52 (0.86 to 2.66)	0.15	1.11 (0.55 to 1.71)	0.76
Emergency surgery	1.16 (0.39 to 3.47)	0.79	0.44 (0.13 to 1.56)	0.21
Surgery (duration in min)
<90	1 (reference)		1 (reference)
90-179	2.15 (0.98 to 6.47)	0.55	1.50 (0.53 to 4.20)	0.44
180 +	6.76 (2.58 to 17.7)	<0.001	2.41 (0.78 to 7.46)	0.13
Blood loss (ml)
0-200	1 (reference)		1 (reference)
201-400	0.94 (0.39 to 2.26)	0.90	1.04 (0.41 to 2.65)	0.93
401-800	2.73 (1.20 to 6.22)	0.017	2.59 (1.03 to 6.53)	0.043
>800	5.60 (2.47 to 12.69)	<0.001	5.37 (2.01 to 14.33)	0.001

Ordinal multivariable logistic regression analysis was performed with the Clavien-Dindo score as the dependent variable. Unadjusted: performed with one covariate at a time; adjusted: performed with all the listed covariates simultaneously

ISSN: 1471-2407