Fig. 3

Construction of WGCNA. A shows the scale-free fitting index of the network topology obtained by the soft-threshold power analysis method. B shows the connectivity of characteristic genes. Red indicates positive correlation and blue indicates negative correlation. C is the analysis of gene significance and module membership in the key module yellow. D level cluster analysis is used to detect co-expression clusters with corresponding color assignments. Each color represents a module in the gene co-expression network constructed by WGCNA. E is to visualize some random genes from the network, using a heat map to describe the TOM between genes in the analysis. On a linear scale, the depth of red is positively correlated with the correlation strength between the pair of modules