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Table 2 Univariate and multivariate logistic regression analyses of treatment response (based on the overall response rate) and clinical characteristics in the total population (N = 28)

From: Gastrointestinal microbiota profile and clinical correlations in advanced EGFR-WT and EGFR-mutant non-small cell lung cancer

Clinical characteristics

Response/total, (N)

Univariate analysis

Multivariate analysis

Odds ratio

(95% CI)

P

Odds ratio

(95% CI)

P

Sex

Male

6/14

ref

   

Female

5/14

0.7 (0.2, 3.4)

0.70

  

BMI

Normal/underweight

7/16

ref

   

Overweight/obese

4/12

0.6 (0.1, 3.0)

0.58

0.8 (0.1, 6.1)

0.84

Smoking status

Never-smoker

7/20

ref

   

Ever-smoker

4/8

1.9 (0.4, 9.8)

0.47

  

Antibiotics

Yes

1/3

0.8 (0.1, 9.4)

0.82

  

No

10/25

ref

   

PPIs

Yes

3/5

2.8 (0.4, 20.5)

0.31

  

No

8/23

ref

   

Laxatives

Yes

2/8

0.4 (0.1, 2.5)

0.34

  

No

9/20

ref

   

Prebiotics/Prebiotics

Yes

4/8

1.9 (0.4, 9.8)

0.47

1.8 (0.2, 14.2)

0.58

No

7/20

ref

   

Supplement

Yes

3/4

5.6 (0.5, 63.3)

0.16

  

No

12/24

ref

   

Lung/pleural metastasis

Yes

5/17

0.3 (0.1, 1.7)

0.19

0.8 (0.1, 6.3)

0.84

No

6/11

ref

   

Brain metastasis

Yes

3/5

2.8 (0.4, 20.4)

0.31

1.5 (0.1, 18.1)

0.75

No

8/23

ref

   

Albumin

< 3.2 g/dL

1/12

ref

   

≥ 3.2 g/dL

10/16

18.3 (1.9, 179.9)

0.01

15.6 (1.3, 182.0)

0.03

Cohort

EGFR-WT

1/13

ref

   

EGFR-mutant

10/15

23.9 (2.4, 240.6)

0.0007

not available

 

Shannon diversity index

 

11/28

1.2 (0.4, 3.8)

0.77

1.0 (0.3, 4.2)

0.97

  1. BMI Body mass index, EGFR Epidermal growth factor receptor, PPI Proton pump inhibitor, WT Wild-type