Fig. 4

Examination of the Predictive Properties of the Signature. Univariate (A) and multivariate (B) regression analyses indicated that the stage and risk score were independent risk factors. The predictive value of the signature was illustrated by the concordance index (C) and ROC curves. ROC curves comparing the signature with age, sex, grade and stage showed the superiority of the risk score compared with other indicators (D). ROC curves at 1, 3 and 5 years were also plotted to reflect the long-term predictive value (E)