Table 4 Multivariate survival analysis comparing prognostic value of CD8 and joint GZMB/CD68 in cohorts 1 and 2 (by Cox regression). Overall survival was used for cohort 1 and disease-free survival for cohort 2. Groups were formed based on immune cell density in the TP25μm zone at the tumour centre. Abbreviations: HR hazard ratio, CI confidence interval, GZMB granzyme B
Model CD8 | Model GZMB/CD68 | ||||||
|---|---|---|---|---|---|---|---|
HR | 95% CI | p | HR | 95% CI | p | ||
Cohort 1 (TNM I-IV) | TNM (I-IV) | 1.639 | 1.10-2.43 | 0.014* | 1.556 | 1.05-2.31 | 0.028* |
Postoperative Tx (no/yes) | 0.62 | 0.25-1.51 | 0.292 | 0.635 | 0.26-1.57 | 0.325 | |
CD8 (low/high) | 0.232 | 0.09-0.58 | 0.002** | ||||
GZMB/CD68 (low/high) | 0.063 | 0.01-0.47 | 0.007** | ||||
Cohort 2 (TNM II) | pT (3/4) | 2.331 | 1.04-5.22 | 0.04* | 2.165 | 0.97-4.83 | 0.059 |
Venous invasion (no/yes) | 1.119 | 0.42-2.99 | 0.822 | 0.992 | 0.37-2.65 | 0.987 | |
CD8 (low/high) | 0.571 | 0.27-1.21 | 0.142 | ||||
GZMB/CD68 (low/high) | 0.181 | 0.06-0.60 | 0.005** | ||||