Fig. 1From: A combined spatial score of granzyme B and CD68 surpasses CD8 as an independent prognostic factor in TNM stage II colorectal cancerStudy design. a shows cohort selection and distinct annotations for ngTMA® construction. b illustrates workflow of digital image analysis for two consecutive quadruple immunohistochemical stainings. Abbreviations: NE, normal epithelium; ME, microenvironment; FR, front; CT, centre; GZMB, granzyme B; PanCK, pancytokeratin; Hx, haematoxylin; IHC, immunohistochemistry; TP, tumour proximityBack to article page