Table 1 Existing scoring systems for risk prediction of colorectal advanced neoplasia
Scoring systems | Investigators | Population | Outcome | Scoring algorithm | High risk criteria | C-statistic |
|---|---|---|---|---|---|---|
Asia-Pacific Colorectal Screening (APCS) score | Yeho et al. (2011) [12] | Derivation cohort: 860 subjects from 11 Asian cities Validation cohort: 1892 subjects from 11 Asian cities | CAN | Age (< 50: 0; 50–69: 2; ≥70: 3) | ≥4 (Max. = 7) | Derivation cohort: 0.66 (0.62–0.70) Validation cohort: 0.64 (0.60–0.68) |
| Â | Â | Â | Sex (male: 1; female: 0) | Â | Â | |
| Â | Â | Â | Family history for first-degree relationship (yes: 2; no: 0) | Â | Â | |
| Â | Â | Â | Smoking (yes: 1; no: 0) | Â | Â | |
Colorectal neoplasia predict (CNP) score | Wong et al. (2013) [1] | Derivation cohort: 2000 subjects from Hong Kong Validation cohort: 3220 subjects from Hong Kong | CN | Age (50–55: 0; 56–70: 1) | ≥3 (Max. = 6) | Derivation cohort: 0.62 (0.61–0.63) Validation cohort: 0.62 (0.61–0.63) |
| Â | Â | Â | Sex (male: 1; female: 0) | Â | Â | |
| Â | Â | Â | Family history for first-degree relationship (yes: 1; no: 0) | Â | Â | |
| Â | Â | Â | Smoking (yes: 1; no: 0) | Â | Â | |
|  |  |  | BMI (< 25 kg/m2: 0; ≥25 kg/m2: 1) |  |  | |
| Â | Â | Â | Diabetes (yes: 1; no: 0) | Â | Â | |
Korean Colorectal Screening (KCS) score | Kim et al. (2014) [3] | Derivation cohort: 3561 subjects from Korean Validation cohort: 1316 subjects from Korean | CAN | Age (< 50: 0; 50–69: 2; ≥70: 4) | ≥4 (Max. = 8) | Validation cohort: 0.68 (0.61–0.76) |
| Â | Â | Â | Sex (male: 1; female: 0) | Â | Â | |
| Â | Â | Â | Family history for first-degree relationship (yes: 1; no: 0) | Â | Â | |
| Â | Â | Â | Smoking (yes: 1; no: 0) | Â | Â | |
|  |  |  | BMI (< 25 kg/m2: 0; ≥25 kg/m2: 1) |  |  | |
Modified APCS score | Sung et al. (2017) [2] | Derivation cohort: 3829 subjects from Hong Kong Validation cohort: 1915 subjects from Hong Kong | CAN | Age (50–54: 0; 55–64: 1; 65–70: 2) | ≥3 (Max. = 6) | Validation cohort: 0.65 (0.61–0.69) |
| Â | Â | Â | Sex (male: 1; female: 0) | Â | Â | |
| Â | Â | Â | Family history for first-degree relationship (yes: 1; no: 0) | Â | Â | |
| Â | Â | Â | Smoking (yes: 1; no: 0) | Â | Â | |
|  |  |  | BMI (< 23 kg/m2: 0; ≥23 kg/m2: 1) |  |  | |
8-point risk score | Sekiguchi et al. (2018) [4] | Derivation cohort: 5218 subjects from Japan | CAN | Age (40–49: 0; 50–59: 2; 60–69: 3; ≥70: 3.5) | ≥5 (Max. = 8) | Derivation cohort: 0.70 (0.67–0.73) Internal validation: 0.70 (0.67–0.73) |
| Â | Â | Â | Sex (male: 1; female: 0) | Â | Â | |
|  |  |  | Family history for first-degree relationship (presence of ≥2 first-degree relatives with colorectal cancer: 2; others: 0) |  |  | |
|  |  |  | Smoking (≤18.5 pack-years: 0; > 18.5 pack-years: 1) |  |  | |
|  |  |  | BMI (≤22.5 kg/m2: 0; > 22.5 kg/m2: 0.5) |  |  |