Table 9 Multivariate Cox regression analysis for overall survival and relapse-free survival in colorectal cancer patients

 Histologic grade, Poor (vs. Well or Moderate)

3.375 (1.431–7.964)

0.005

0.828 (0.328–2.092)

0.69

 N stage, 1–3 (vs. N stage, 0)

0.61 (0.094–3.982)

0.606

4.262 (1.826–9.943)

0.001

 TNM Stage, III or IV (vs. TNM Stage, I or II)

2.543 (0.981–6.592)

0.055

1.123 (0.212–5.946)

0.892

 p53 (DO-7) IHC, positive, > 55% (vs. negative, ≤55%)

4.098 (1.197–14.031)

0.025

0.77 (0.371–1.599)

0.483

 Histologic grade, Poor (vs. Well or Moderate)

3.114 (1.323–7.33)

0.009

0.852 (0.338–2.148)

0.734

 N stage, 1–3 (vs. N stage, 0)

0.683 (0.101–4.632)

0.696

4.262 (1.826–9.943)

0.001

 TNM Stage, III or IV (vs. TNM Stage, I or II)

2.76 (1.067–7.142)

2.76

1.113 (0.209–5.917)

0.9

 p53 (Bp53–11) IHC, positive, > 50% (vs. negative, ≤50%)

2.531 (0.926–6.918)

0.07

0.759 (0.369–1.56)

0.452

 Histologic grade, Poor (vs. Well or Moderate)

3.04 (1.288–7.178)

0.011

0.854 (0.338–2.156)

0.738

 N stage, 1–3 (vs. N stage, 0)

0.587 (0.081–4.242)

0.598

4.262 (1.826–9.943)

0.001

 TNM Stage, III or IV (vs. TNM Stage, I or II)

2.674 (1.036–6.903)

0.042

1.125 (0.214–5.928)

0.889

 p53 (SP5) IHC, positive, > 30% (vs. negative, ≤30%)

9.897 (1.327–73.831)

0.025

0.788 (0.371–1.676)

0.536

 Histologic grade, Poor (vs. Well or Moderate)

3.077 (1.312–7.221)

0.01

0.836 (0.33–2.114)

0.705

 N stage, 1–3 (vs. N stage, 0)

0.722 (0.083–6.314)

0.769

4.262 (1.826–9.943)

0.001

 TNM Stage, III or IV (vs. TNM Stage, I or II)

3.122 (1.219–8)

0.018

1.115 (0.211–5.878)

0.898