From: Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer
Characteristics | OS | RFS | ||
---|---|---|---|---|
HR (95% CI) | p | HR (95% CI) | p | |
Sex, female (vs. male) | 0.646 (0.263–1.588) | 0.341 | 0.985 (0.473–2.052) | 0.968 |
Age, y ≥ 50 (vs. <  50) | 1.394 (0.187–10.369) | 0.745 | 1.874 (0.255–13.759) | 0.537 |
Histologic grade, Poor (vs. Well or Moderate) | 3.324 (1.419–7.784) | 0.006 | 1.211 (0.494–2.964) | 0.676 |
Site, Left side (vs. Right side) | 0.725 (0.31–1.696) | 0.725 | 1.003 (0.469–2.144) | 0.993 |
Tumor size, ≥ 4.5 cm (vs. <  4.5 cm) | 1.95 (0.833–4.565) | 0.124 | 2.109 (1.014–4.387) | 0.046 |
T stage, T4 (vs. T1–3) | 3.262 (1.367–7.779) | 0.008 | 2.695 (1.231–5.899) | 0.013 |
N stage, N1–3 (vs. N0) | 3.129 (1.224–8) | 0.017 | 4.262 (1.826–9.943) | 0.001 |
TNM Stage, III or IV (vs. TNM Stage, I or II) | 3.326 (1.301–8.503) | 0.012 | 3.775 (1.679–8.489) | 0.001 |
CEA, <  5 ng/ml (vs. ≥ 5 ng/ml) | 1.389 (0.542–3.557) | 0.493 | 1.048 (0.425–2.584) | 0.919 |
p53 (DO-7) IHC, positive, > 55% (vs. negative, ≤55%) | 4.352 (1.288–14.712) | 0.018 | 0.919 (0.446–1.894) | 0.818 |
p53 (Bp53–11) IHC, positive, > 50% (vs. negative, ≤50%) | 2.79 (1.029–7.566) | 0.044 | 0.854 (0.417–1.752) | 0.668 |
p53 (SP5) IHC, positive, > 30% (vs. negative, ≤30%) | 10.861 (1.46–80.775) | 0.02 | 0.908 (0.432–1.912) | 0.8 |
TP53, Wild type (vs. Variation type) | 1.739 (0.588–5.142) | 0.317 | 1.36 (0.583–3.174) | 0.477 |