Skip to main content

Table 8 Univariate Cox proportional hazards regression analysis for overall survival and relapse-free survival in colorectal cancer patients

From: Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer

Characteristics

OS

RFS

HR (95% CI)

p

HR (95% CI)

p

Sex, female (vs. male)

0.646 (0.263–1.588)

0.341

0.985 (0.473–2.052)

0.968

Age, y ≥ 50 (vs. <  50)

1.394 (0.187–10.369)

0.745

1.874 (0.255–13.759)

0.537

Histologic grade, Poor (vs. Well or Moderate)

3.324 (1.419–7.784)

0.006

1.211 (0.494–2.964)

0.676

Site, Left side (vs. Right side)

0.725 (0.31–1.696)

0.725

1.003 (0.469–2.144)

0.993

Tumor size, ≥ 4.5 cm (vs. <  4.5 cm)

1.95 (0.833–4.565)

0.124

2.109 (1.014–4.387)

0.046

T stage, T4 (vs. T1–3)

3.262 (1.367–7.779)

0.008

2.695 (1.231–5.899)

0.013

N stage, N1–3 (vs. N0)

3.129 (1.224–8)

0.017

4.262 (1.826–9.943)

0.001

TNM Stage, III or IV (vs. TNM Stage, I or II)

3.326 (1.301–8.503)

0.012

3.775 (1.679–8.489)

0.001

CEA, <  5 ng/ml (vs. ≥ 5 ng/ml)

1.389 (0.542–3.557)

0.493

1.048 (0.425–2.584)

0.919

p53 (DO-7) IHC, positive, > 55% (vs. negative, ≤55%)

4.352 (1.288–14.712)

0.018

0.919 (0.446–1.894)

0.818

p53 (Bp53–11) IHC, positive, > 50% (vs. negative, ≤50%)

2.79 (1.029–7.566)

0.044

0.854 (0.417–1.752)

0.668

p53 (SP5) IHC, positive, > 30% (vs. negative, ≤30%)

10.861 (1.46–80.775)

0.02

0.908 (0.432–1.912)

0.8

TP53, Wild type (vs. Variation type)

1.739 (0.588–5.142)

0.317

1.36 (0.583–3.174)

0.477