Table 4 Sensitivity, specificity, and accuracy of p53 immunohistochemistry for detecting TP53 variation
From: Clinical significance of p53 protein expression and TP53 variation status in colorectal cancer
Variation type | Sensitivity | Specificity | Accuracy |
|---|---|---|---|
p53 (DO-7) | |||
 Binary (IHC: wild/aberrant) | 87.2% | 61.8% | 80.4% |
 Binary (IHC: positive/negative) | 71.8% | 69.1% | 71.1% |
 Missense variation | 87.2% | 82.3% | 85.3% |
 Nonsense/frameshift variation | 70.7% | 93.3% | 88.7% |
 Wild type | 61.8% | 87.9% | 80.9% |
p53 (Bp53–11) | |||
 Binary  (IHC: wild/aberrant) | 92.6% | 69.1% | 86.3% |
 Binary (IHC: positive/negative) | 68.5% | 74.5% | 70.1% |
 Missense variation | 91.7% | 82.3% | 87.7% |
 Nonsense/frameshift variation | 85.4% | 97.5% | 95.1% |
 Wild type | 70.4% | 93.3% | 86.8% |
p53 (SP5) | |||
 Binary (IHC: wild/aberrant) | 91.9% | 76.4% | 87.7% |
 Binary (IHC: positive/negative) | 74.5% | 49.1% | 67.6% |
 Missense variation | 90.8% | 92.7% | 92.2% |
 Nonsense/frameshift variation | 87.8% | 94.5% | 93.1% |
 Wild type | 77.8% | 92.6% | 88.2% |